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Research Article

Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci

  • Alexandra Zhernakova,

    Affiliations: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Complex Genetics Section, Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Eli A. Stahl,

    Affiliations: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

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  • Gosia Trynka,

    Affiliation: Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

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  • Soumya Raychaudhuri,

    Affiliations: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Eleanora A. Festen,

    Affiliation: Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

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  • Lude Franke,

    Affiliations: Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

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  • Harm-Jan Westra,

    Affiliation: Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

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  • Rudolf S. N. Fehrmann,

    Affiliation: Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

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  • Fina A. S. Kurreeman,

    Affiliations: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

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  • Brian Thomson,

    Affiliation: Broad Institute, Cambridge, Massachusetts, United States of America

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  • Namrata Gupta,

    Affiliation: Broad Institute, Cambridge, Massachusetts, United States of America

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  • Jihane Romanos,

    Affiliation: Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

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  • Ross McManus,

    Affiliation: Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College, St James's Hospital, Dublin, Ireland

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  • Anthony W. Ryan,

    Affiliation: Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College, St James's Hospital, Dublin, Ireland

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  • Graham Turner,

    Affiliation: Department of Clinical Medicine and Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College, St James's Hospital, Dublin, Ireland

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  • Elisabeth Brouwer,

    Affiliation: Department of Rheumatology and Clinical Immunology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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  • Marcel D. Posthumus,

    Affiliation: Department of Rheumatology and Clinical Immunology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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  • Elaine F. Remmers,

    Affiliation: Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Francesca Tucci,

    Affiliation: European Laboratory for Food Induced Disease, University of Naples Federico II, Naples, Italy

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  • Rene Toes,

    Affiliation: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands

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  • Elvira Grandone,

    Affiliation: Unita' di Aterosclerosi e Trombosi, I.R.C.C.S Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Foggia, Italy

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  • Maria Cristina Mazzilli,

    Affiliation: Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

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  • Anna Rybak,

    Affiliation: Department of Gastroenterology, Hepatology, and Immunology, Children's Memorial Health Institute, Warsaw, Poland

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  • Bozena Cukrowska,

    Affiliation: Department of Pathology, Children's Memorial Health Institute, Warsaw, Poland

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  • Marieke J. H. Coenen,

    Affiliation: Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Timothy R. D. J. Radstake,

    Affiliation: Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Piet L. C. M. van Riel,

    Affiliation: Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Yonghong Li,

    Affiliation: Celera, Alameda, California, United States of America

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  • Paul I. W. de Bakker,

    Affiliations: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands

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  • Peter K. Gregersen,

    Affiliation: The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, United States of America

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  • Jane Worthington,

    Affiliation: Arthritis Research Campaign–Epidemiology Unit, The University of Manchester, Manchester, United Kingdom

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  • Katherine A. Siminovitch,

    Affiliation: Department of Medicine, University of Toronto, Mount Sinai Hospital and University Health Network, Toronto, Canada

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  • Lars Klareskog,

    Affiliation: Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden

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  • Tom W. J. Huizinga,

    Affiliation: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands

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  • Cisca Wijmenga equal contributor,

    equal contributor Contributed equally to this work with: Cisca Wijmenga, Robert M. Plenge

    Affiliation: Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

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  • Robert M. Plenge equal contributor mail

    equal contributor Contributed equally to this work with: Cisca Wijmenga, Robert M. Plenge

    rplenge@partners.org

    Affiliations: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Published: February 24, 2011
  • DOI: 10.1371/journal.pgen.1002004

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