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Research Article

Evolution Meets Disease: Penetrance and Functional Epistasis of Mitochondrial tRNA Mutations

  • Raquel Moreno-Loshuertos equal contributor,

    equal contributor Contributed equally to this work with: Raquel Moreno-Loshuertos, Gustavo Ferrín

    Affiliation: Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain

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  • Gustavo Ferrín equal contributor,

    equal contributor Contributed equally to this work with: Raquel Moreno-Loshuertos, Gustavo Ferrín

    Affiliation: Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain

    Current address: Unidad de Investigación, Hospital Universitario Reina Sofía, Córdoba, Spain

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  • Rebeca Acín-Pérez,

    Affiliation: Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain

    Current address: Department of Neurology and Neuroscience, Weill Medical College of Cornell University, Ithaca, New York, United States of America

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  • M. Esther Gallardo,

    Affiliation: Departamento de Bioquímica, Instituto de Investigaciones Biomédicas “Alberto Sols,” Facultad de Medicina, CSIC–Universidad Autónoma de Madrid, CIBERER, ISCIII, Madrid, Spain

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  • Carlo Viscomi,

    Affiliation: Division of Molecular Neurogenetics, Istituto Neurologico “Carlo Besta,” Milano, Italy

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  • Acisclo Pérez-Martos,

    Affiliation: Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain

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  • Massimo Zeviani,

    Affiliation: Division of Molecular Neurogenetics, Istituto Neurologico “Carlo Besta,” Milano, Italy

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  • Patricio Fernández-Silva,

    Affiliation: Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain

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  • José Antonio Enríquez mail

    jaenriquez@cnic.es

    Affiliations: Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain, Regenerative Cardiology Department, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain

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  • Published: April 21, 2011
  • DOI: 10.1371/journal.pgen.1001379

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