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Research Article

Quantitative Fitness Analysis Shows That NMD Proteins and Many Other Protein Complexes Suppress or Enhance Distinct Telomere Cap Defects

  • Stephen Gregory Addinall equal contributor,

    equal contributor Contributed equally to this work with: Stephen Gregory Addinall, Eva-Maria Holstein, Conor Lawless

    Affiliations: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

    X
  • Eva-Maria Holstein equal contributor,

    equal contributor Contributed equally to this work with: Stephen Gregory Addinall, Eva-Maria Holstein, Conor Lawless

    Affiliations: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

    X
  • Conor Lawless equal contributor,

    equal contributor Contributed equally to this work with: Stephen Gregory Addinall, Eva-Maria Holstein, Conor Lawless

    Affiliation: Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

    X
  • Min Yu,

    Affiliations: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

    X
  • Kaye Chapman,

    Affiliations: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

    Current address: Health Protection Agency North East, Citygate, Newcastle upon Tyne, United Kingdom

    X
  • A. Peter Banks,

    Affiliations: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

    X
  • Hien-Ping Ngo,

    Affiliation: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom

    X
  • Laura Maringele,

    Affiliation: Crucible Laboratory, Institute for Ageing and Health, Newcastle University Centre for Life, Newcastle upon Tyne, United Kingdom

    X
  • Morgan Taschuk,

    Affiliations: Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom, School of Computing Science, Newcastle University, Newcastle Upon Tyne, United Kingdom

    X
  • Alexander Young,

    Affiliations: Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom, School of Mathematics and Statistics, Newcastle University, Newcastle upon Tyne, United Kingdom

    X
  • Adam Ciesiolka,

    Affiliations: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

    X
  • Allyson Lurena Lister,

    Affiliations: Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom, School of Computing Science, Newcastle University, Newcastle Upon Tyne, United Kingdom

    X
  • Anil Wipat,

    Affiliations: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom, School of Computing Science, Newcastle University, Newcastle Upon Tyne, United Kingdom

    X
  • Darren James Wilkinson,

    Affiliations: Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom, School of Mathematics and Statistics, Newcastle University, Newcastle upon Tyne, United Kingdom

    X
  • David Lydall mail

    d.a.lydall@ncl.ac.uk

    Affiliations: Institute for Cell and Molecular Biosciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom, Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom

    X
  • Published: April 07, 2011
  • DOI: 10.1371/journal.pgen.1001362

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