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Research Article

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

  • Clement T. Y. Chan,

    Affiliations: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Madhu Dyavaiah,

    Affiliation: Department of Biomedical Sciences, Gen*NY*sis Center for Excellence in Cancer Genomics, University at Albany, State University of New York, Rensselaer, New York, United States of America

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  • Michael S. DeMott,

    Affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Koli Taghizadeh,

    Affiliation: Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Peter C. Dedon mail,

    pcdedon@mit.edu (PCD); tbegley@albany.edu (TJB)

    Affiliations: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Thomas J. Begley mail

    pcdedon@mit.edu (PCD); tbegley@albany.edu (TJB)

    Affiliation: Department of Biomedical Sciences, Gen*NY*sis Center for Excellence in Cancer Genomics, University at Albany, State University of New York, Rensselaer, New York, United States of America

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  • Published: December 16, 2010
  • DOI: 10.1371/journal.pgen.1001247

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