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Research Article

Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities

  • Adam C. Naj,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Gary W. Beecham,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Eden R. Martin,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Paul J. Gallins,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Eric H. Powell,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Ioanna Konidari,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Patrice L. Whitehead,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Guiqing Cai,

    Affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Vahram Haroutunian,

    Affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America

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  • William K. Scott,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Jeffery M. Vance,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Michael A. Slifer,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Harry E. Gwirtsman,

    Affiliation: Veterans Affairs Medical Center, Nashville, Tennessee, United States of America

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  • John R. Gilbert,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Jonathan L. Haines equal contributor,

    equal contributor Contributed equally to this work with: Jonathan L. Haines, Joseph D. Buxbaum, Margaret A. Pericak-Vance

    Affiliation: Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Joseph D. Buxbaum equal contributor,

    equal contributor Contributed equally to this work with: Jonathan L. Haines, Joseph D. Buxbaum, Margaret A. Pericak-Vance

    Affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Margaret A. Pericak-Vance equal contributor mail

    equal contributor Contributed equally to this work with: Jonathan L. Haines, Joseph D. Buxbaum, Margaret A. Pericak-Vance

    mpericak@med.miami.edu

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Published: September 23, 2010
  • DOI: 10.1371/journal.pgen.1001130

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