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Research Article

Altered Gene Expression and DNA Damage in Peripheral Blood Cells from Friedreich's Ataxia Patients: Cellular Model of Pathology

  • Astrid C. Haugen,

    Affiliation: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

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  • Nicholas A. Di Prospero,

    Affiliation: Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America

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  • Joel S. Parker,

    Affiliation: Expression Analysis, Durham, North Carolina, United States of America

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  • Rick D. Fannin,

    Affiliation: Laboratory of Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

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  • Jeff Chou,

    Affiliation: Laboratory of Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

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  • Joel N. Meyer,

    Affiliation: Nicholas School of the Environment, Duke University, Durham, North Carolina, United States of America

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  • Christopher Halweg,

    Affiliation: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

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  • Jennifer B. Collins,

    Affiliation: Laboratory of Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

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  • Alexandra Durr,

    Affiliations: Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Université Pierre et Marie Curie, Paris, France, Département de Génétique et Embryologie, Hôpital Pitié-Salpêtrière, Paris, France

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  • Kenneth Fischbeck,

    Affiliation: Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America

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  • Bennett Van Houten mail

    vanhoutenb@upmc.edu

    Affiliations: Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Published: January 15, 2010
  • DOI: 10.1371/journal.pgen.1000812

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