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Research Article

Multiple Organ System Defects and Transcriptional Dysregulation in the Nipbl+/− Mouse, a Model of Cornelia de Lange Syndrome

  • Shimako Kawauchi equal contributor,

    equal contributor Contributed equally to this work with: Shimako Kawauchi, Anne L. Calof

    Affiliations: Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California, United States of America, Developmental Biology Center, University of California Irvine, Irvine, California, United States of America, Center for Hearing Research, University of California Irvine, Irvine, California, United States of America

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  • Anne L. Calof equal contributor mail,

    equal contributor Contributed equally to this work with: Shimako Kawauchi, Anne L. Calof

    alcalof@uci.edu (ALC); adlander@uci.edu (ADL)

    Affiliations: Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California, United States of America, Developmental Biology Center, University of California Irvine, Irvine, California, United States of America, Center for Hearing Research, University of California Irvine, Irvine, California, United States of America, Center for Complex Biological Systems, University of California Irvine, Irvine, California, United States of America

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  • Rosaysela Santos,

    Affiliations: Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California, United States of America, Developmental Biology Center, University of California Irvine, Irvine, California, United States of America

    X
  • Martha E. Lopez-Burks,

    Affiliations: Developmental Biology Center, University of California Irvine, Irvine, California, United States of America, Department of Developmental and Cell Biology, University of California Irvine, Irvine, California, United States of America

    X
  • Clint M. Young,

    Affiliations: Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California, United States of America, Developmental Biology Center, University of California Irvine, Irvine, California, United States of America

    X
  • Michelle P. Hoang,

    Affiliations: Developmental Biology Center, University of California Irvine, Irvine, California, United States of America, Department of Developmental and Cell Biology, University of California Irvine, Irvine, California, United States of America

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  • Abigail Chua,

    Affiliations: Developmental Biology Center, University of California Irvine, Irvine, California, United States of America, Department of Developmental and Cell Biology, University of California Irvine, Irvine, California, United States of America

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  • Taotao Lao,

    Affiliation: Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania, United States of America

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  • Mark S. Lechner,

    Affiliation: Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania, United States of America

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  • Jeremy A. Daniel,

    Affiliation: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Andre Nussenzweig,

    Affiliation: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Leonard Kitzes,

    Affiliations: Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California, United States of America, Center for Hearing Research, University of California Irvine, Irvine, California, United States of America

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  • Kyoko Yokomori,

    Affiliation: Department of Biological Chemistry, University of California Irvine, Irvine, California, United States of America

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  • Benedikt Hallgrimsson,

    Affiliation: Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada

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  • Arthur D. Lander mail

    alcalof@uci.edu (ALC); adlander@uci.edu (ADL)

    Affiliations: Developmental Biology Center, University of California Irvine, Irvine, California, United States of America, Center for Complex Biological Systems, University of California Irvine, Irvine, California, United States of America, Department of Developmental and Cell Biology, University of California Irvine, Irvine, California, United States of America

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  • Published: September 18, 2009
  • DOI: 10.1371/journal.pgen.1000650

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