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Research Article

Reduced Neutrophil Count in People of African Descent Is Due To a Regulatory Variant in the Duffy Antigen Receptor for Chemokines Gene

  • David Reich mail,

    reich@genetics.med.harvard.edu (DR); James.Wilson3@va.gov (JGW)

    Affiliations: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Michael A. Nalls,

    Affiliations: Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America, Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

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  • W. H. Linda Kao,

    Affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Ermeg L. Akylbekova,

    Affiliation: Jackson Heart Study Analysis Group, Jackson State University, Jackson, Mississippi, United States of America

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  • Arti Tandon,

    Affiliations: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Nick Patterson,

    Affiliation: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • James Mullikin,

    Affiliation: Comparative Genomics Unit, Genome Technology Branch, National Human Genome Research Institute, Rockville, Maryland, United States of America

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  • Wen-Chi Hsueh,

    Affiliation: Division of Medical Genetics, Department of Medicine, Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • Ching-Yu Cheng,

    Affiliations: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Inherited Disease Research Branch, National Human Genome Research Institute, Baltimore, Maryland, United States of America

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  • Josef Coresh,

    Affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Eric Boerwinkle,

    Affiliation: Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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  • Man Li,

    Affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Alicja Waliszewska,

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Laboratory of Molecular Immunology, Center for Neurologic Disease, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Julie Neubauer,

    Affiliation: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Rongling Li,

    Affiliation: Department of Preventive Medicine, Center for Genomics and Bioinformatics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Tennille S. Leak,

    Affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Lynette Ekunwe,

    Affiliation: Jackson Heart Study Analysis Group, Jackson State University, Jackson, Mississippi, United States of America

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  • Joe C. Files,

    Affiliation: Department of Medicine, Division of Hematology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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  • Cheryl L. Hardy,

    Affiliation: Department of Medicine, Division of Hematology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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  • Joseph M. Zmuda,

    Affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Herman A. Taylor,

    Affiliations: Jackson State University, Jackson, Mississippi, United States of America, Tougaloo College, Jackson, Mississippi, United States of America, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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  • Elad Ziv,

    Affiliations: Division of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America, Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America

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  • Tamara B. Harris,

    Affiliation: Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

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  • James G. Wilson mail

    reich@genetics.med.harvard.edu (DR); James.Wilson3@va.gov (JGW)

    Affiliations: V.A. Medical Center, Jackson, Mississippi, United States of America, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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  • Published: January 30, 2009
  • DOI: 10.1371/journal.pgen.1000360

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