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Research Article

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

  • Manching Ku equal contributor,

    equal contributor Contributed equally to this work with: Manching Ku, Richard P. Koche, Esther Rheinbay

    Affiliations: Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Richard P. Koche equal contributor,

    equal contributor Contributed equally to this work with: Manching Ku, Richard P. Koche, Esther Rheinbay

    Affiliations: Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Division of Health Sciences and Technology, MIT, Cambridge, Massachusetts, United States of America

    X
  • Esther Rheinbay equal contributor,

    equal contributor Contributed equally to this work with: Manching Ku, Richard P. Koche, Esther Rheinbay

    Affiliations: Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Bioinformatics Program and Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

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  • Eric M. Mendenhall,

    Affiliations: Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Mitsuhiro Endoh,

    Affiliation: RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Japan

    X
  • Tarjei S. Mikkelsen,

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Division of Health Sciences and Technology, MIT, Cambridge, Massachusetts, United States of America

    X
  • Aviva Presser,

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America

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  • Chad Nusbaum,

    Affiliation: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

    X
  • Xiaohui Xie,

    Affiliation: Department of Computer Science, University of California Irvine, Irvine, California, United States of America

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  • Andrew S. Chi,

    Affiliations: Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Mazhar Adli,

    Affiliations: Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Simon Kasif,

    Affiliation: Bioinformatics Program and Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

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  • Leon M. Ptaszek,

    Affiliations: Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America, Stowers Medical Institute, Center for Regenerative Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Chad A. Cowan,

    Affiliations: Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America, Stowers Medical Institute, Center for Regenerative Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Eric S. Lander,

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Whitehead Institute for Biomedical Research, MIT, Cambridge, Massachusetts, United States of America

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  • Haruhiko Koseki,

    Affiliation: RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Japan

    X
  • Bradley E. Bernstein mail

    Bernstein.Bradley@mgh.harvard.edu

    Affiliations: Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America

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  • Published: October 31, 2008
  • DOI: 10.1371/journal.pgen.1000242

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