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Research Article

A Myo6 Mutation Destroys Coordination between the Myosin Heads, Revealing New Functions of Myosin VI in the Stereocilia of Mammalian Inner Ear Hair Cells

  • Ronna Hertzano equal contributor,

    equal contributor Contributed equally to this work with: Ronna Hertzano, Ella Shalit, Agnieszka K. Rzadzinska

    Affiliation: Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel

    Current address: Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America

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  • Ella Shalit equal contributor,

    equal contributor Contributed equally to this work with: Ronna Hertzano, Ella Shalit, Agnieszka K. Rzadzinska

    Affiliation: Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel

    X
  • Agnieszka K. Rzadzinska equal contributor,

    equal contributor Contributed equally to this work with: Ronna Hertzano, Ella Shalit, Agnieszka K. Rzadzinska

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

    X
  • Amiel A. Dror,

    Affiliation: Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel

    X
  • Lin Song,

    Affiliation: Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Uri Ron,

    Affiliation: Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

    X
  • Joshua T. Tan,

    Affiliation: Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, United States of America

    X
  • Alina Starovolsky Shitrit,

    Affiliation: Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel

    X
  • Helmut Fuchs,

    Affiliation: Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics, Neuherberg, Germany

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  • Tama Hasson,

    Affiliation: Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, United States of America

    Current address: UCLA College of Letters and Science, Honors and Undergraduate Programs, University of California at Los Angeles, Los Angeles, California, United States of America

    X
  • Nir Ben-Tal,

    Affiliation: Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

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  • H. Lee Sweeney,

    Affiliation: Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Martin Hrabe de Angelis,

    Affiliations: Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics, Neuherberg, Germany, Technical University of Munich, Munich, Germany

    X
  • Karen P. Steel,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Karen B. Avraham mail

    karena@post.tau.ac.il

    Affiliation: Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel

    X
  • Published: October 03, 2008
  • DOI: 10.1371/journal.pgen.1000207

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