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Research Article

Genetic Analysis of Completely Sequenced Disease-Associated MHC Haplotypes Identifies Shuffling of Segments in Recent Human History

  • James A Traherne equal contributor,

    equal contributor Contributed equally to this work with: James A Traherne, Roger Horton, Anne N Roberts, Marcos M Miretti

    Affiliation: Department of Pathology, Immunology Division, University of Cambridge, Cambridge, United Kingdom

    X
  • Roger Horton equal contributor,

    equal contributor Contributed equally to this work with: James A Traherne, Roger Horton, Anne N Roberts, Marcos M Miretti

    Affiliation: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

    X
  • Anne N Roberts equal contributor,

    equal contributor Contributed equally to this work with: James A Traherne, Roger Horton, Anne N Roberts, Marcos M Miretti

    Affiliation: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • Marcos M Miretti equal contributor,

    equal contributor Contributed equally to this work with: James A Traherne, Roger Horton, Anne N Roberts, Marcos M Miretti

    Affiliation: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

    X
  • Matthew E Hurles,

    Affiliation: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

    X
  • C. Andrew Stewart,

    Affiliation: Department of Pathology, Immunology Division, University of Cambridge, Cambridge, United Kingdom

    X
  • Jennifer L Ashurst,

    Affiliation: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

    X
  • Alexey M Atrazhev,

    Affiliation: Alberta Diabetes Institute (ADI), Department of Medical Microbiology and Immunology, Division of Dermatology and Cutaneous Sciences, University of Alberta, Edmonton, Canada

    X
  • Penny Coggill,

    Affiliation: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

    X
  • Sophie Palmer,

    Affiliation: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

    X
  • Jeff Almeida,

    Affiliation: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

    X
  • Sarah Sims,

    Affiliation: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

    X
  • Laurens G Wilming,

    Affiliation: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

    X
  • Jane Rogers,

    Affiliation: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

    X
  • Pieter J. de Jong,

    Affiliation: Children's Hospital Oakland Research Institute, Oakland, California, United States of America

    X
  • Mary Carrington,

    Affiliation: Basic Research Program, SAIC-Frederick, Inc., Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, United States of America

    X
  • John F Elliott,

    Affiliation: Alberta Diabetes Institute (ADI), Department of Medical Microbiology and Immunology, Division of Dermatology and Cutaneous Sciences, University of Alberta, Edmonton, Canada

    X
  • Stephen Sawcer,

    Affiliation: Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • John A Todd,

    Affiliation: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Cambridge, United Kingdom

    X
  • John Trowsdale,

    Affiliation: Department of Pathology, Immunology Division, University of Cambridge, Cambridge, United Kingdom

    X
  • Stephan Beck mail

    To whom correspondence should be addressed. E-mail: beck@sanger.ac.uk

    Affiliation: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

    X
  • Published: January 27, 2006
  • DOI: 10.1371/journal.pgen.0020009

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