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February 21, 2025

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05/08/2025

research article

Unveiling the intercompartmental signaling axis: Mitochondrial to ER Stress Response (MERSR) and its impact on proteostasis

This article identifies a previously unknown Mitochondria to ER Stress Response (MERSR), showing that mitochondrial stress modulates the ER’s unfolded protein response. By inhibiting IRE1 and enhancing PERK-eIF2α signaling, MERSR improves proteostasis and reduces aggregates in C. elegans models, revealing new intercompartmental regulation.

Image credit: pgen.1011700

Unveiling the intercompartmental signaling axis: Mitochondrial to ER Stress Response (MERSR) and its impact on proteostasis

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05/06/2025

research article

A novel male accessory gland peptide reduces female post-mating receptivity in the brown planthopper

The authors characterize the post-mating response (PMR) in the brown planthopper Nilaparvata lugens and aim to identify seminal fluid factors similar to the Drosophila sex peptide. They find that N. lugens shows a distinct PMR that lasts for about 4 days, marked by a change in female behavior with decreased receptivity to males and increased oviposition. 

Image credit: pgen.1011699

A novel male accessory gland peptide reduces female post-mating receptivity in the brown planthopper

05/12/2025

research article

Loss of Heterozygosity associated with ubiquitous environments in yeast

The authors examine how ubiquitous environmental conditions affect mutational mechanisms, focusing on loss of heterozygosity (LOH) in a diploid hybrid baker’s yeast strain. They show that exposures such as blue light, calorie restriction and oxidative stress enhance LOH, with each condition producing distinct LOH patterns and mutational signatures, highlighting environment-specific mechanisms of genome alteration.

Image credit: pgen.1011692

Loss of Heterozygosity associated with ubiquitous environments in yeast

05/02/2025

research article

Glycolytic disruption restricts Drosophila melanogaster larval growth via the cytokine Upd3

The authors show that simultaneous loss of Ldh and Gpdh1 in Drosophila larvae disrupts glycolytic metabolism and causes developmental arrest, not solely due to metabolic defects but through elevated Upd3 expression and Jak/Stat signaling. This work reveals how metabolic stress in muscle can trigger systemic growth regulation across tissues.

Glycolytic disruption restricts Drosophila melanogaster larval growth via the cytokine Upd3

Image credit: pgen.1011690

05/22/2025

research article

Identification of SanA as a novel regulator of peptidoglycan biogenesis in Escherichia coli

In this study, the authors identify sanA, an ORF of unknown function encoding a predicted IM-anchored protein as a factor contributing to balanced synthesis of PG in E. coli. Absence of SanA increased the rate of nascent PG strand incorporation, and restored growth and viability to several mutants defective in either cell division or cell elongation.

Identification of SanA as a novel regulator of peptidoglycan biogenesis in Escherichia coli

Image credit: pgen.1011712

05/09/2025

research article

Functional characterization of eicosanoid signaling in Drosophila development

The authors identify a single prostanoid receptor in Drosophila, named Prostaglandin Receptor (PGR), which is activated by PGE2 and PGD2. They show that PGR and a Drosophila PGE synthase are essential for tracheal development, revealing a simplified but functional eicosanoid signaling pathway in flies.

Functional characterization of eicosanoid signaling in Drosophila development

Image credit: pgen.1011705

05/27/2025

research article

Variant-specific priors clarify colocalisation analysis

Here, the authors propose and implement an approach for specifying variant-specific prior probabilities in the coloc method, improving colocalisation performance and gene prioritization in GWAS-eQTL analyses.

Variant-specific priors clarify colocalisation analysis

Image credit: pgen.1011697

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