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Research Article

Cancer Evolution Is Associated with Pervasive Positive Selection on Globally Expressed Genes

  • Sheli L. Ostrow,

    Affiliation: Rachel & Menachem Mendelovitch Evolutionary Processes of Mutation & Natural Selection Research Laboratory, Department of Genetics, the Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

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  • Ruth Barshir,

    Affiliation: Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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  • James DeGregori,

    Affiliation: Department of Biochemistry and Molecular Genetics, Program in Molecular Biology, Integrated Department of Immunology, University of Colorado School of Medicine, Aurora, Colorado, United States of America

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  • Esti Yeger-Lotem,

    Affiliation: Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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  • Ruth Hershberg mail

    ruthersh@tx.technion.ac.il

    Affiliation: Rachel & Menachem Mendelovitch Evolutionary Processes of Mutation & Natural Selection Research Laboratory, Department of Genetics, the Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

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  • Published: March 06, 2014
  • DOI: 10.1371/journal.pgen.1004239

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