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Research Article

Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production

  • Julio E. Molineros equal contributor,

    equal contributor Contributed equally to this work with: Julio E. Molineros, Amit K. Maiti, Celi Sun

    Affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Amit K. Maiti equal contributor,

    equal contributor Contributed equally to this work with: Julio E. Molineros, Amit K. Maiti, Celi Sun

    Affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Celi Sun equal contributor,

    equal contributor Contributed equally to this work with: Julio E. Molineros, Amit K. Maiti, Celi Sun

    Affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Loren L. Looger,

    Affiliation: Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, United States of America

    X
  • Shizhong Han,

    Affiliations: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, United States of America

    X
  • Xana Kim-Howard,

    Affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Stuart Glenn,

    Affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Adam Adler,

    Affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Jennifer A. Kelly,

    Affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Timothy B. Niewold,

    Affiliation: Mayo Clinic, Division of Rheumatology and Department of Immunology, Rochester, Minnesota, United States of America

    X
  • Gary S. Gilkeson,

    Affiliation: Division of Rheumatology, Medical University of South Carolina, Charleston, South Carolina, United States of America

    X
  • Elizabeth E. Brown,

    Affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Graciela S. Alarcón,

    Affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Jeffrey C. Edberg,

    Affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Michelle Petri,

    Affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

    X
  • Rosalind Ramsey-Goldman,

    Affiliation: Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

    X
  • John D. Reveille,

    Affiliation: Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

    X
  • Luis M. Vilá,

    Affiliation: Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico

    X
  • Barry I. Freedman,

    Affiliation: Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Betty P. Tsao,

    Affiliation: Division of Rheumatology, Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Lindsey A. Criswell,

    Affiliation: Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, California, United States of America

    X
  • Chaim O. Jacob,

    Affiliation: Department of Medicine, University of Southern California, Los Angeles, California, United States of America

    X
  • Jason H. Moore,

    Affiliation: Department of Genetics, Dartmouth Medical School, Lebanon, New Hampshire, United States of America

    X
  • Timothy J. Vyse,

    Affiliations: Division of Genetics and Molecular Medicine, King's College London, London, United Kingdom, Division of Immunology, Infection and Inflammatory Diseases, Kings College London, London, United Kingdom

    X
  • Carl L. Langefeld,

    Affiliation: Department of Biostatistical Sciences, Wake Forest University Health Sciences, Wake Forest, North Carolina, United States of America

    X
  • Joel M. Guthridge,

    Affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Patrick M. Gaffney,

    Affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Kathy L. Moser,

    Affiliations: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

    X
  • R. Hal Scofield,

    Affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Marta E. Alarcón-Riquelme,

    Affiliations: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Centro de Genómica e Investigación Oncológica (GENyO)–Pfizer/Universidad de Granada/Junta de Andalucía, Granada, Spain

    X
  • on behalf of the BIOLUPUS Network,

    Membership of the BIOLUPUS Network is available in Text S1.

    X
  • Scott M. Williams,

    Affiliation: Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, United States of America

    X
  • Joan T. Merrill,

    Affiliation: Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Judith A. James,

    Affiliations: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

    X
  • Kenneth M. Kaufman,

    Affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Robert P. Kimberly,

    Affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • John B. Harley,

    Affiliation: Cincinnati Children's Hospital Medical Center and the U.S. Department of Veterans Affairs Medical Center, Cincinnati, Ohio, United States of America

    X
  • Swapan K. Nath mail

    Swapan-Nath@omrf.org

    Affiliation: Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

    X
  • Published: February 18, 2013
  • DOI: 10.1371/journal.pgen.1003222

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