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Research Article

Selective Pressure Causes an RNA Virus to Trade Reproductive Fitness for Increased Structural and Thermal Stability of a Viral Enzyme

  • Moshe Dessau equal contributor,

    equal contributor Contributed equally to this work with: Moshe Dessau, Daniel Goldhill

    Affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

    X
  • Daniel Goldhill equal contributor,

    equal contributor Contributed equally to this work with: Moshe Dessau, Daniel Goldhill

    Affiliation: Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America

    X
  • Robert L. McBride,

    Affiliation: Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America

    Current address: Sapphire Energy, San Diego, California, United States of America

    X
  • Paul E. Turner mail,

    paul.turner@yale.edu (PET); yorgo.modis@yale.edu (YM)

    Affiliation: Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America

    X
  • Yorgo Modis mail

    paul.turner@yale.edu (PET); yorgo.modis@yale.edu (YM)

    Affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

    X
  • Published: November 29, 2012
  • DOI: 10.1371/journal.pgen.1003102

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