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Research Article

Discovering Thiamine Transporters as Targets of Chloroquine Using a Novel Functional Genomics Strategy

  • Zhiwei Huang,

    Affiliations: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Institute of Biological Sciences and Biotechnology, Donghua University, Shanghai, China

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  • Sankaranarayanan Srinivasan,

    Affiliation: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Jianhuai Zhang,

    Affiliation: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Kaifu Chen,

    Affiliations: Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Yongxiang Li,

    Affiliation: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Wei Li,

    Affiliations: Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Florante A. Quiocho,

    Affiliation: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Xuewen Pan mail

    xuewenp@bcm.edu

    Affiliations: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Center of Molecular Discovery, Baylor College of Medicine, Houston, Texas, United States of America

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  • Published: November 29, 2012
  • DOI: 10.1371/journal.pgen.1003083

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