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Research Article

Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations

  • Laura C. Greaves mail,

    laura.greaves@ncl.ac.uk

    Affiliations: Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Joanna L. Elson,

    Affiliation: Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Marco Nooteboom,

    Affiliation: Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • John P. Grady,

    Affiliation: Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Geoffrey A. Taylor,

    Affiliation: Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Robert W. Taylor,

    Affiliation: Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • John C. Mathers,

    Affiliations: Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Human Nutrition Research Centre, Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle Upon Tyne, United Kingdom

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  • Thomas B. L. Kirkwood,

    Affiliations: Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne, United Kingdom

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  • Doug M. Turnbull

    Affiliations: Newcastle University Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.pgen.1003082

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