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Research Article

Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors

  • Geeta N. Eick,

    Affiliations: Institute of Ecology and Evolution, University of Oregon, Eugene, Oregon, United States of America, Howard Hughes Medical Institute, Eugene, Oregon, United States of America

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  • Jennifer K. Colucci,

    Affiliation: Biochemistry Department, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Michael J. Harms,

    Affiliation: Institute of Ecology and Evolution, University of Oregon, Eugene, Oregon, United States of America

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  • Eric A. Ortlund,

    Affiliation: Biochemistry Department, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Joseph W. Thornton mail

    joet1@uchicago.edu

    Affiliations: Institute of Ecology and Evolution, University of Oregon, Eugene, Oregon, United States of America, Howard Hughes Medical Institute, Eugene, Oregon, United States of America, Department of Human Genetics and Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.pgen.1003072

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