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Research Article

Reduced Prostasin (CAP1/PRSS8) Activity Eliminates HAI-1 and HAI-2 Deficiency–Associated Developmental Defects by Preventing Matriptase Activation

  • Roman Szabo,

    Affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Katiuchia Uzzun Sales,

    Affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Peter Kosa,

    Affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Natalia A. Shylo,

    Affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Sine Godiksen,

    Affiliations: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America, Department of Cellular and Molecular Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark, Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark

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  • Karina K. Hansen,

    Affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Stine Friis,

    Affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • J. Silvio Gutkind,

    Affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Lotte K. Vogel,

    Affiliation: Department of Cellular and Molecular Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark

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  • Edith Hummler,

    Affiliation: Pharmacology and Toxicology Department, University de Lausanne, Lausanne, Switzerland

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  • Eric Camerer,

    Affiliations: INSERM U970, Paris Cardiovascular Research Centre, Paris, France, Université Paris-Descartes, Paris, France

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  • Thomas H. Bugge mail

    thomas.bugge@nih.gov

    Affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: August 30, 2012
  • DOI: 10.1371/journal.pgen.1002937

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