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Research Article

Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis

  • Michael Inouye mail,

    minouye@unimelb.edu.au

    Affiliations: Medical Systems Biology, Departments of Pathology and of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia, Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

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  • Samuli Ripatti,

    Affiliations: Institute of Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Johannes Kettunen,

    Affiliations: Institute of Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Leo-Pekka Lyytikäinen,

    Affiliation: Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland

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  • Niku Oksala,

    Affiliations: Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland, Division of Vascular Surgery, Department of Surgery, Tampere University Hospital, Tampere, Finland

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  • Pirkka-Pekka Laurila,

    Affiliations: Institute of Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Department of Medical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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  • Antti J. Kangas,

    Affiliation: Computational Medicine, Institute of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland

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  • Pasi Soininen,

    Affiliations: Computational Medicine, Institute of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland

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  • Markku J. Savolainen,

    Affiliations: Computational Medicine, Institute of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland, Department of Internal Medicine, Clinical Research Center, University of Oulu, Oulu, Finland

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  • Jorma Viikari,

    Affiliation: Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland

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  • Mika Kähönen,

    Affiliation: Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland

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  • Markus Perola,

    Affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Veikko Salomaa,

    Affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Olli Raitakari,

    Affiliation: Research Centre of Applied and Preventive Cardiovascular Medicine and Department of Clinical Physiology, University of Turku and Turku University Hospital, Turku, Finland

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  • Terho Lehtimäki,

    Affiliation: Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland

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  • Marja-Riitta Taskinen,

    Affiliation: Department of Medicine, University of Helsinki, Helsinki, Finland

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  • Marjo-Riitta Järvelin,

    Affiliations: Biocenter Oulu, University of Oulu, Oulu, Finland, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom, Department of Public Health Science and General Practice, University of Oulu, Oulu, Finland

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  • Mika Ala-Korpela,

    Affiliations: Computational Medicine, Institute of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland, NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, Department of Internal Medicine, Clinical Research Center, University of Oulu, Oulu, Finland, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom

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  • Aarno Palotie,

    Affiliations: Institute of Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland, Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Department of Medical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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  • Paul I. W. de Bakker

    Affiliations: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Epidemiology, University Medical Center Utrecht, Utrecht, The Netherlands

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  • Published: August 16, 2012
  • DOI: 10.1371/journal.pgen.1002907

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