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Research Article

Mutational Signatures of De-Differentiation in Functional Non-Coding Regions of Melanoma Genomes

  • Stephen C. J. Parker,

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Jared Gartner,

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Isabel Cardenas-Navia,

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Xiaomu Wei,

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Hatice Ozel Abaan,

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Subramanian S. Ajay,

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Nancy F. Hansen,

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Lingyun Song,

    Affiliation: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America

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  • Umesh K. Bhanot,

    Affiliation: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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  • J. Keith Killian,

    Affiliation: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Yevgeniy Gindin,

    Affiliations: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Graduate Program in Bioinformatics, Boston University, Boston, Massachusetts, United States of America

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  • Robert L. Walker,

    Affiliation: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Paul S. Meltzer,

    Affiliation: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • James C. Mullikin,

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Terrence S. Furey,

    Affiliation: Department of Genetics, Department of Biology, Lineberger Comprehensive Cancer Center, and Carolina Center for Genome Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Gregory E. Crawford,

    Affiliation: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America

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  • Steven A. Rosenberg,

    Affiliation: National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Yardena Samuels mail,

    samuelsy@mail.nih.gov (YS); emargulies@illumina.com (EHM)

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Elliott H. Margulies mail

    samuelsy@mail.nih.gov (YS); emargulies@illumina.com (EHM)

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    Current address: Illumina Cambridge, Chesterford Research Park, Saffron Walden, United Kingdom

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  • Published: August 09, 2012
  • DOI: 10.1371/journal.pgen.1002871

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