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Research Article

Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans

  • Pawel K. Olszewski,

    Affiliations: Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden, Minnesota Obesity Center, University of Minnesota, St. Paul, Minnesota, United States of America

    Current address: Department of Biological Sciences, University of Waikato, Hamilton, New Zealand

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  • Jan Rozman,

    Affiliations: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Molecular Nutritional Medicine, Else Kröner-Fresenius Center and ZIEL Research Center for Nutrition and Food Sciences, Technische Universität München, Freising-Weihenstephan, Germany

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  • Josefin A. Jacobsson,

    Affiliation: Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden

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  • Birgit Rathkolb,

    Affiliations: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Chair for Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-Universität München, München, Germany

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  • Siv Strömberg,

    Affiliation: Molecular Cell Biology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden

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  • Wolfgang Hans,

    Affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Anica Klockars,

    Affiliation: Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden

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  • Johan Alsiö,

    Affiliation: Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden

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  • Ulf Risérus,

    Affiliation: Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden

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  • Lore Becker,

    Affiliations: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Department of Neurology, Friedrich-Baur-Institut, Ludwig-Maximilians-Universität München, München, Germany

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  • Sabine M. Hölter,

    Affiliations: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany

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  • Ralf Elvert,

    Affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

    Current address: Sanofi-Aventis GmbH, Frankfurt am Main, Germany

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  • Nicole Ehrhardt,

    Affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

    Current address: Department of Medical Genetics, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Valérie Gailus-Durner,

    Affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Helmut Fuchs,

    Affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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  • Robert Fredriksson,

    Affiliation: Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden

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  • Eckhard Wolf,

    Affiliation: Chair for Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-Universität München, München, Germany

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  • Thomas Klopstock,

    Affiliation: Department of Neurology, Friedrich-Baur-Institut, Ludwig-Maximilians-Universität München, München, Germany

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  • Wolfgang Wurst,

    Affiliations: Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany, Max-Planck-Institute for Psychiatry, München, Germany, Technical University München-Weihenstephan, Lehrstuhl für Entwicklungsgenetik c/o Helmholtz Zentrum München, Neuherberg, Germany, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Munich, Germany

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  • Allen S. Levine,

    Affiliation: Minnesota Obesity Center, University of Minnesota, St. Paul, Minnesota, United States of America

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  • Claude Marcus,

    Affiliation: Department for Clinical Science, Intervention, and Technology, Karolinska Institutet, Division of Pediatrics, National Childhood Obesity Centre, Stockholm, Sweden

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  • Martin Hrabě de Angelis,

    Affiliations: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany

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  • Martin Klingenspor,

    Affiliation: Molecular Nutritional Medicine, Else Kröner-Fresenius Center and ZIEL Research Center for Nutrition and Food Sciences, Technische Universität München, Freising-Weihenstephan, Germany

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  • Helgi B. Schiöth ,

    Affiliation: Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden

    These authors were joint senior authors on this work.

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  • Manfred W. Kilimann mail

    manfred.kilimann@neuro.uu.se

    Affiliation: Molecular Cell Biology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden

    These authors were joint senior authors on this work.

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  • Published: March 15, 2012
  • DOI: 10.1371/journal.pgen.1002568

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