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Research Article

A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

  • Eimear E. Kenny,

    Affiliation: Department of Computer Sciences, Columbia University, New York, New York, United States of America

    Current address: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

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  • Itsik Pe'er,

    Affiliation: Department of Computer Sciences, Columbia University, New York, New York, United States of America

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  • Amir Karban,

    Affiliation: Department of Gastroenterology, Rambam Health Care Campus, B. Rappaport Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

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  • Laurie Ozelius,

    Affiliation: Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Adele A. Mitchell,

    Affiliation: Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Sok Meng Ng,

    Affiliation: Department of Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut, United States of America

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  • Monica Erazo,

    Affiliation: Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Harry Ostrer,

    Affiliation: Department of Pathology, Albert Einstein College of Medicine, New York, New York, United States of America

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  • Clara Abraham,

    Affiliation: Department of Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut, United States of America

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  • Maria T. Abreu,

    Affiliation: Division of Gastroenterology, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Gil Atzmon,

    Affiliation: Genetic Core for Longevity, Institute for Aging Research and the Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Nir Barzilai,

    Affiliation: Genetic Core for Longevity, Institute for Aging Research and the Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Steven R. Brant,

    Affiliations: Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Susan Bressman,

    Affiliations: Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, United States of America, The Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Edward R. Burns,

    Affiliation: Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Yehuda Chowers,

    Affiliation: Department of Gastroenterology, Rambam Health Care Campus, B. Rappaport Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

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  • Lorraine N. Clark,

    Affiliation: Department of Pathology and Cell Biology, Columbia University, New York, New York, United States of America

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  • Ariel Darvasi,

    Affiliation: The Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel

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  • Dana Doheny,

    Affiliation: Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Richard H. Duerr,

    Affiliations: Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Rami Eliakim,

    Affiliation: Department of Gastroenterology and Hepatology, Sheba Medical Center, Raman Gan, Israel

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  • Nir Giladi,

    Affiliation: Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel

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  • Peter K. Gregersen,

    Affiliation: Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York, United States of America

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  • Hakon Hakonarson,

    Affiliation: Center for Applied Genomics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Michelle R. Jones,

    Affiliation: Division of Endocrinology, Diabetes, and Metabolism, Graduate Program in Biomedical Sciences and Translational Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Karen Marder,

    Affiliations: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

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  • Dermot P. B. McGovern,

    Affiliations: Department of Translational Medicine, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Jennifer Mulle,

    Affiliation: Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Avi Orr-Urtreger,

    Affiliation: Genetic Institute, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel

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  • Deborah D. Proctor,

    Affiliation: Department of Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut, United States of America

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  • Ann Pulver,

    Affiliations: Epidemiology-Genetics Program in Schizophrenia, Bipolar Disorders, and Related Disorders, Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Jerome I. Rotter,

    Affiliation: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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  • Mark S. Silverberg,

    Affiliation: IBD Group, Mount Sinai Hospital, University of Toronto, Toronto, Canada

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  • Thomas Ullman,

    Affiliation: Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Stephen T. Warren,

    Affiliations: Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America, Departments of Biochemistry and Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Matti Waterman,

    Affiliation: Department of Gastroenterology, Rambam Health Care Campus, B. Rappaport Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

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  • Wei Zhang,

    Affiliation: Department of Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut, United States of America

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  • Aviv Bergman,

    Affiliation: Department of Systems and Computational Biology, Albert Einstein College of Medicine, New York, New York, United States of America

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  • Lloyd Mayer,

    Affiliation: Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Seymour Katz,

    Affiliation: Albert Einstein College of Medicine, North Shore University Hospital-Long Island Jewish Hospital Systems, St. Francis Hospital, Great Neck, New York, United States of America

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  • Robert J. Desnick,

    Affiliation: Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Judy H. Cho mail,

    judy.cho@yale.edu (JH Cho) (JC); inga.peter@mssm.edu (I Peter) (IP)

    Affiliation: Department of Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut, United States of America

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  • Inga Peter mail

    judy.cho@yale.edu (JH Cho) (JC); inga.peter@mssm.edu (I Peter) (IP)

    Affiliation: Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Published: March 08, 2012
  • DOI: 10.1371/journal.pgen.1002559

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