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Research Article

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

  • Décio L. Eizirik mail,

    deizirik@ulb.ac.be (DLE); mcnop@ulb.ac.be (MC)

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Michael Sammeth,

    Affiliation: Functional Bioinformatics (FBI), Centre Nacional d'Anàlisi Genòmica (CNAG), Barcelona, Spain

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  • Thomas Bouckenooghe,

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Guy Bottu,

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Giorgia Sisino,

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Mariana Igoillo-Esteve,

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Fernanda Ortis,

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Izortze Santin,

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Maikel L. Colli,

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Jenny Barthson,

    Affiliation: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Luc Bouwens,

    Affiliation: Cell Differentiation Unit, Diabetes Research Centre, Vrije Universiteit Brussel (VUB), Brussels, Belgium

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  • Linda Hughes,

    Affiliation: Oxford Centre for Diabetes, Endocrinology, and Metabolism (OCDEM), Churchill Hospital, Oxford, United Kingdom

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  • Lorna Gregory,

    Affiliation: Oxford Centre for Diabetes, Endocrinology, and Metabolism (OCDEM), Churchill Hospital, Oxford, United Kingdom

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  • Gerton Lunter,

    Affiliation: Oxford Centre for Diabetes, Endocrinology, and Metabolism (OCDEM), Churchill Hospital, Oxford, United Kingdom

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  • Lorella Marselli,

    Affiliation: Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy

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  • Piero Marchetti,

    Affiliation: Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy

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  • Mark I. McCarthy,

    Affiliations: Oxford Centre for Diabetes, Endocrinology, and Metabolism (OCDEM), Churchill Hospital, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom

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  • Miriam Cnop mail

    deizirik@ulb.ac.be (DLE); mcnop@ulb.ac.be (MC)

    Affiliations: Laboratory of Experimental Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium, Division of Endocrinology, Erasmus Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium

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  • Published: March 08, 2012
  • DOI: 10.1371/journal.pgen.1002552

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