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Research Article

Down-Regulating Sphingolipid Synthesis Increases Yeast Lifespan

  • Xinhe Huang,

    Affiliation: Department of Molecular and Cellular Biochemistry and the Lucille Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America

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  • Jun Liu,

    Affiliations: Department of Molecular and Cellular Biochemistry and the Lucille Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu, China

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  • Robert C. Dickson mail

    bobd@uky.edu

    Affiliation: Department of Molecular and Cellular Biochemistry and the Lucille Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America

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  • Published: February 02, 2012
  • DOI: 10.1371/journal.pgen.1002493

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