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Research Article

A Comprehensive Analysis of Shared Loci between Systemic Lupus Erythematosus (SLE) and Sixteen Autoimmune Diseases Reveals Limited Genetic Overlap

  • Paula S. Ramos mail,

    ramosp@musc.edu

    Affiliation: Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America

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  • Lindsey A. Criswell,

    Affiliation: Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, California, United States of America

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  • Kathy L. Moser,

    Affiliation: Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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  • Mary E. Comeau,

    Affiliation: Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

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  • Adrienne H. Williams,

    Affiliation: Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

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  • Nicholas M. Pajewski,

    Affiliation: Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

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  • Sharon A. Chung,

    Affiliation: Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, California, United States of America

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  • Robert R. Graham,

    Affiliation: Immunology Biomarkers Group, Genentech, South San Francisco, California, United States of America

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  • Raphael Zidovetzki,

    Affiliation: Department of Cell Biology and Neuroscience, University of California Riverside, Riverside, California, United States of America

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  • Jennifer A. Kelly,

    Affiliation: Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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  • Kenneth M. Kaufman,

    Affiliation: Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

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  • Chaim O. Jacob,

    Affiliation: Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Timothy J. Vyse,

    Affiliation: Division of Genetics and Molecular Medicine, King's College London, London, United Kingdom

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  • Betty P. Tsao,

    Affiliation: David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Robert P. Kimberly,

    Affiliation: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Patrick M. Gaffney,

    Affiliation: Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America

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  • Marta E. Alarcón-Riquelme,

    Affiliations: Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America, Centro de Genómica y Investigaciones Oncológicas, Pfizer-Universidad de Granada-Junta de Andalucía, Granada, Spain

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  • John B. Harley,

    Affiliation: Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

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  • Carl D. Langefeld,

    Affiliation: Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

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  • for The International Consortium on the Genetics of Systemic Erythematosus (SLEGEN)

    Membership of SLEGEN is provided in the Acknowledgments.

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  • Published: December 08, 2011
  • DOI: 10.1371/journal.pgen.1002406

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