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Research Article

Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence

  • Atsushi Kaneda mail,

    kaneda@genome.rcast.u-tokyo.ac.jp

    Affiliations: Genome Science Division, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, PRESTO, Japan Science and Technology Agency (JST), Tokyo, Japan

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  • Takanori Fujita,

    Affiliation: Genome Science Division, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Motonobu Anai,

    Affiliation: Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Shogo Yamamoto,

    Affiliation: Genome Science Division, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Genta Nagae,

    Affiliation: Genome Science Division, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Masato Morikawa,

    Affiliation: Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Shingo Tsuji,

    Affiliation: Genome Science Division, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Masanobu Oshima,

    Affiliation: Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan

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  • Kohei Miyazono,

    Affiliation: Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Hiroyuki Aburatani

    Affiliation: Genome Science Division, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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  • Published: November 03, 2011
  • DOI: 10.1371/journal.pgen.1002359

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