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Research Article

Identification of Type 1 Diabetes–Associated DNA Methylation Variable Positions That Precede Disease Diagnosis

  • Vardhman K. Rakyan equal contributor mail,

    equal contributor Contributed equally to this work with: Vardhman K. Rakyan, Huriya Beyan, Thomas A. Down

    v.rakyan@qmul.ac.uk (VKR); r.d.g.leslie@qmul.ac.uk (RDL)

    Affiliation: Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    X
  • Huriya Beyan equal contributor,

    equal contributor Contributed equally to this work with: Vardhman K. Rakyan, Huriya Beyan, Thomas A. Down

    Affiliation: Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    X
  • Thomas A. Down equal contributor,

    equal contributor Contributed equally to this work with: Vardhman K. Rakyan, Huriya Beyan, Thomas A. Down

    Affiliation: The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, United Kingdom

    X
  • Mohammed I. Hawa,

    Affiliation: Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    X
  • Siarhei Maslau,

    Affiliation: The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge, United Kingdom

    X
  • Deeqo Aden,

    Affiliation: Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    X
  • Antoine Daunay,

    Affiliation: Laboratory for Functional Genomics, Fondation Jean-Dausset – CEPH, Paris, France

    X
  • Florence Busato,

    Affiliation: Laboratory for Epigenetics, Centre National de Génotypage, CEA – Institut de Génomique, Evry, France

    X
  • Charles A. Mein,

    Affiliation: The Genome Centre, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, The Sir John Vane Science Centre, London, United Kingdom

    X
  • Burkhard Manfras,

    Affiliation: Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Medical Center Ulm and Center of Excellence “Metabolic Disorders” Baden-Württemberg, Ulm, Germany

    X
  • Kerith-Rae M. Dias,

    Affiliation: The Genome Centre, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, The Sir John Vane Science Centre, London, United Kingdom

    X
  • Christopher G. Bell,

    Affiliation: UCL Cancer Institute, University College London, London, United Kingdom

    X
  • Jörg Tost,

    Affiliations: Laboratory for Functional Genomics, Fondation Jean-Dausset – CEPH, Paris, France, Laboratory for Epigenetics, Centre National de Génotypage, CEA – Institut de Génomique, Evry, France

    X
  • Bernhard O. Boehm,

    Affiliation: Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Medical Center Ulm and Center of Excellence “Metabolic Disorders” Baden-Württemberg, Ulm, Germany

    X
  • Stephan Beck,

    Affiliation: UCL Cancer Institute, University College London, London, United Kingdom

    X
  • R. David Leslie mail

    v.rakyan@qmul.ac.uk (VKR); r.d.g.leslie@qmul.ac.uk (RDL)

    Affiliation: Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    X
  • Published: September 29, 2011
  • DOI: 10.1371/journal.pgen.1002300

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