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Research Article

Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA

  • Rudolf S. N. Fehrmann,

    Affiliation: Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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  • Ritsert C. Jansen equal contributor,

    equal contributor Contributed equally to this work with: Ritsert C. Jansen, Jan H. Veldink, Harm-Jan Westra

    Affiliation: Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands

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  • Jan H. Veldink equal contributor,

    equal contributor Contributed equally to this work with: Ritsert C. Jansen, Jan H. Veldink, Harm-Jan Westra

    Affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands

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  • Harm-Jan Westra equal contributor,

    equal contributor Contributed equally to this work with: Ritsert C. Jansen, Jan H. Veldink, Harm-Jan Westra

    Affiliation: Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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  • Danny Arends,

    Affiliation: Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands

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  • Marc Jan Bonder,

    Affiliation: Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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  • Jingyuan Fu,

    Affiliation: Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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  • Patrick Deelen,

    Affiliation: Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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  • Harry J. M. Groen,

    Affiliation: Department of Pulmonology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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  • Asia Smolonska,

    Affiliation: Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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  • Rinse K. Weersma,

    Affiliations: Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands, Department of Gastroenterology and Hepatology, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

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  • Robert M. W. Hofstra,

    Affiliation: Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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  • Wim A. Buurman,

    Affiliation: NUTRIM School for Nutrition, Toxicology, and Metabolism, Department of General Surgery, Maastricht University Medical Center, Maastricht, The Netherlands

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  • Sander Rensen,

    Affiliation: NUTRIM School for Nutrition, Toxicology, and Metabolism, Department of General Surgery, Maastricht University Medical Center, Maastricht, The Netherlands

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  • Marcel G. M. Wolfs,

    Affiliation: Department of Pathology and Medical Biology, Medical Biology Section, Molecular Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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  • Mathieu Platteel,

    Affiliation: Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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  • Alexandra Zhernakova,

    Affiliation: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands

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  • Clara C. Elbers,

    Affiliation: Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Eleanora M. Festen,

    Affiliation: Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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  • Gosia Trynka,

    Affiliation: Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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  • Marten H. Hofker,

    Affiliation: Department of Pathology and Medical Biology, Medical Biology Section, Molecular Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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  • Christiaan G. J. Saris,

    Affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands

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  • Roel A. Ophoff,

    Affiliations: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands, Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, California, United States of America

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  • Leonard H. van den Berg,

    Affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands

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  • David A. van Heel,

    Affiliation: Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

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  • Cisca Wijmenga,

    Affiliation: Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

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  • Gerard J. te Meerman ,

    Affiliation: Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

    These authors also contributed equally to this work.

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  • Lude Franke mail

    lude@ludesign.nl

    Affiliations: Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    These authors also contributed equally to this work.

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  • Published: August 04, 2011
  • DOI: 10.1371/journal.pgen.1002197

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