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Research Article

A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

  • Lihong Zhao,

    Affiliations: The Jackson Laboratory, Bar Harbor, Maine, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • Stefka D. Spassieva,

    Affiliation: Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America

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  • Thomas J. Jucius,

    Affiliations: The Jackson Laboratory, Bar Harbor, Maine, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • Leonard D. Shultz,

    Affiliation: The Jackson Laboratory, Bar Harbor, Maine, United States of America

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  • H. Elizabeth Shick,

    Affiliation: Department of Neuroscience, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America

    Current address: Department of Neurological Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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  • Wendy B. Macklin,

    Affiliation: Department of Neuroscience, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America

    Current address: Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado, United States of America

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  • Yusuf A. Hannun,

    Affiliation: Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America

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  • Lina M. Obeid,

    Affiliation: Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America

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  • Susan L. Ackerman mail

    susan.ackerman@jax.org

    Affiliations: The Jackson Laboratory, Bar Harbor, Maine, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • Published: May 19, 2011
  • DOI: 10.1371/journal.pgen.1002063

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