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Research Article

Viral Genome Segmentation Can Result from a Trade-Off between Genetic Content and Particle Stability

  • Samuel Ojosnegros,

    Affiliation: Centro de Biología Molecular “Severo Ochoa,” CSIC-UAM, Madrid, Spain

    Current address: California Institute of Technology, Division of Biology, Pasadena, California, United States of America

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  • Juan García-Arriaza,

    Affiliations: Centro de Biología Molecular “Severo Ochoa,” CSIC-UAM, Madrid, Spain, Centro Nacional de Biotecnología, CSIC, Madrid, Spain

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  • Cristina Escarmís,

    Affiliation: Centro de Biología Molecular “Severo Ochoa,” CSIC-UAM, Madrid, Spain

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  • Susanna C. Manrubia,

    Affiliation: Laboratorio de Evolución Molecular, Centro de Astrobiología (CSIC/INTA), Instituto Nacional de Técnica Aeroespacial, Madrid, Spain

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  • Celia Perales,

    Affiliation: Centro de Biología Molecular “Severo Ochoa,” CSIC-UAM, Madrid, Spain

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  • Armando Arias,

    Affiliation: Centro de Biología Molecular “Severo Ochoa,” CSIC-UAM, Madrid, Spain

    Current address: Department of Virology, Imperial College London, London, United Kingdom

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  • Mauricio García Mateu,

    Affiliation: Centro de Biología Molecular “Severo Ochoa,” CSIC-UAM, Madrid, Spain

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  • Esteban Domingo mail

    edomingo@cbm.uam.es

    Affiliations: Centro de Biología Molecular “Severo Ochoa,” CSIC-UAM, Madrid, Spain, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain

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  • Published: March 17, 2011
  • DOI: 10.1371/journal.pgen.1001344

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