Advertisement
Research Article

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

  • Elizabeth K. Speliotes equal contributor mail,

    equal contributor Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

    espeliot@med.umich.edu (EKS); iborecki@wustl.edu (IBB)

    Affiliations: Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

    X
  • Laura M. Yerges-Armstrong equal contributor,

    equal contributor Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

    Affiliation: Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Jun Wu equal contributor,

    equal contributor Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

    Affiliation: Division of Statistical Genomics, Department of Genetics, Washington University, Saint Louis, Missouri, United States of America

    X
  • Ruben Hernaez equal contributor,

    equal contributor Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

    Affiliations: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Division of General Internal Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, United States of America, Department of Internal Medicine, Washington Hospital Center, Washington D.C., United States of America

    X
  • Lauren J. Kim equal contributor,

    equal contributor Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

    Affiliation: Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Cameron D. Palmer,

    Affiliation: Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America

    X
  • Vilmundur Gudnason,

    Affiliations: Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

    X
  • Gudny Eiriksdottir,

    Affiliation: Icelandic Heart Association, Kopavogur, Iceland

    X
  • Melissa E. Garcia,

    Affiliation: Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Lenore J. Launer,

    Affiliation: Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Michael A. Nalls,

    Affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Jeanne M. Clark,

    Affiliations: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Division of General Internal Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America

    X
  • Braxton D. Mitchell,

    Affiliation: Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Alan R. Shuldiner,

    Affiliations: Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Geriatric Research and Education Clinical Center (GRECC), Veterans Administration Medical Center, Baltimore, Maryland, United States of America

    X
  • Johannah L. Butler,

    Affiliations: Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America, Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America

    X
  • Marta Tomas,

    Affiliations: Cardiovascular Epidemiology and Genetics, Institut Municipal d'Investigació Mèdica, Barcelona, Spain, CIBER Epidemiología y Salud Pública, Barcelona, Spain

    X
  • Udo Hoffmann,

    Affiliations: Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Shih-Jen Hwang,

    Affiliation: Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, United States of America

    X
  • Joseph M. Massaro,

    Affiliations: Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Christopher J. O'Donnell,

    Affiliations: Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, United States of America, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

    X
  • Dushyant V. Sahani,

    Affiliation: Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Veikko Salomaa,

    Affiliation: Chronic Disease Epidemiology Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland

    X
  • Eric E. Schadt,

    Affiliation: Pacific Biosciences, Menlo Park, California, United States of America

    X
  • Stephen M. Schwartz,

    Affiliations: Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

    X
  • David S. Siscovick,

    Affiliation: Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America

    X
  • NASH CRN ,

    For membership information, please see Acknowledgments.

    X
  • GIANT Consortium ,

    For membership information, please see Acknowledgments.

    X
  • MAGIC Investigators ,

    For membership information, please see Acknowledgments.

    X
  • Benjamin F. Voight,

    Affiliation: Broad Institute, Cambridge, Massachusetts, United States of America

    X
  • J. Jeffrey Carr,

    Affiliation: Departments of Radiologic Sciences, Internal Medicine-Cardiology, and Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Mary F. Feitosa,

    Affiliation: Division of Statistical Genomics, Department of Genetics, Washington University, Saint Louis, Missouri, United States of America

    X
  • Tamara B. Harris,

    Affiliation: Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Caroline S. Fox,

    Affiliations: Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, United States of America, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

    X
  • Albert V. Smith equal contributor,

    equal contributor Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

    Affiliation: Icelandic Heart Association, Kopavogur, Iceland

    X
  • W. H. Linda Kao equal contributor,

    equal contributor Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

    Affiliations: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America

    X
  • Joel N. Hirschhorn equal contributor,

    equal contributor Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

    Affiliations: Broad Institute, Cambridge, Massachusetts, United States of America, Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Ingrid B. Borecki equal contributor mail,

    equal contributor Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki

    espeliot@med.umich.edu (EKS); iborecki@wustl.edu (IBB)

    Affiliation: Division of Statistical Genomics, Department of Genetics, Washington University, Saint Louis, Missouri, United States of America

    X
  • GOLD Consortium

    For membership information, please see Acknowledgments.

    X
  • Published: March 10, 2011
  • DOI: 10.1371/journal.pgen.1001324

Reader Comments (0)

Post a new comment on this article