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Research Article

Simultaneous Disruption of Two DNA Polymerases, Polη and Polζ, in Avian DT40 Cells Unmasks the Role of Polη in Cellular Response to Various DNA Lesions

  • Kouji Hirota,

    Affiliation: CREST Research Project, Japan Science and Technology, Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Eiichiro Sonoda,

    Affiliation: CREST Research Project, Japan Science and Technology, Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Takuo Kawamoto,

    Affiliation: CREST Research Project, Japan Science and Technology, Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Akira Motegi,

    Affiliation: CREST Research Project, Japan Science and Technology, Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Chikahide Masutani,

    Affiliation: Solution-Oriented Research for Science and Technology (SORST), Japan Science and Technology Agency, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan

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  • Fumio Hanaoka,

    Affiliation: Solution-Oriented Research for Science and Technology (SORST), Japan Science and Technology Agency, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan

    Current address: Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan

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  • Dávid Szüts,

    Affiliation: St. George's, University of London, London, United Kingdom

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  • Shigenori Iwai,

    Affiliation: Division of Chemistry, Graduate School of Engineering Science, Osaka University, Osaka, Japan

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  • Julian E. Sale,

    Affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Alan Lehmann,

    Affiliation: Genome Damage and Stability Centre, University of Sussex, Brighton, United Kingdom

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  • Shunichi Takeda mail

    stakeda@rg.med.kyoto-u.ac.jp

    Affiliation: CREST Research Project, Japan Science and Technology, Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Published: October 07, 2010
  • DOI: 10.1371/journal.pgen.1001151

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