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Research Article

Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans

  • Alexandre Benedetto,

    Affiliations: Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America, Children's Hospital, Vanderbilt University, Nashville, Tennessee, United States of America, London Centre for Nanotechnology, University College London, London, United Kingdom

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  • Catherine Au,

    Affiliations: Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America, Center for Molecular Toxicology, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Daiana Silva Avila,

    Affiliations: Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America, Children's Hospital, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Dejan Milatovic,

    Affiliations: Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America, Center for Molecular Toxicology, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Michael Aschner mail

    michael.aschner@vanderbilt.edu

    Affiliations: Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America, Children's Hospital, Vanderbilt University, Nashville, Tennessee, United States of America, Center for Molecular Toxicology, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Published: August 26, 2010
  • DOI: 10.1371/journal.pgen.1001084

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