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Research Article

The 5p15.33 Locus Is Associated with Risk of Lung Adenocarcinoma in Never-Smoking Females in Asia

  • Chao Agnes Hsiung equal contributor mail,

    equal contributor Contributed equally to this work with: Chao Agnes Hsiung, Qing Lan

    hsiung@nhri.org.tw (CAH); qingl@mail.nih.gov (QL)

    Affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan

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  • Qing Lan equal contributor mail,

    equal contributor Contributed equally to this work with: Chao Agnes Hsiung, Qing Lan

    hsiung@nhri.org.tw (CAH); qingl@mail.nih.gov (QL)

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Yun-Chul Hong,

    Affiliations: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea

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  • Chien-Jen Chen,

    Affiliations: Genomics Research Center, Academia Sinica, Taipei, Taiwan, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan

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  • H. Dean Hosgood III,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • I-Shou Chang,

    Affiliation: National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan

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  • Nilanjan Chatterjee,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Paul Brennan,

    Affiliation: International Agency for Research on Cancer, Lyon, France

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  • Chen Wu,

    Affiliation: Departments of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

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  • Wei Zheng,

    Affiliation: Department of Medicine, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Gee-Chen Chang,

    Affiliations: Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Institute of Biomedical Sciences, National Chung-Hsing University, Taichung, Taiwan, School of Medicine, China Medical University, Taichung, Taiwan

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  • Tangchun Wu,

    Affiliation: Institute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, China

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  • Jae Yong Park,

    Affiliations: Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea, Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea, Cancer Research Center, Kyungpook National University Hospital, Daegu, Republic of Korea

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  • Chin-Fu Hsiao,

    Affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan

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  • Yeul Hong Kim,

    Affiliations: Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea, Department of Internal Medicine and Division of Brain, Korea University College of Medicine, Seoul, Republic of Korea, Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea

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  • Hongbing Shen,

    Affiliation: Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China

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  • Adeline Seow,

    Affiliation: Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore

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  • Meredith Yeager,

    Affiliations: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America, Core Genotyping Facility, Advanced Technology Program, Science Applications International Corporation-Frederick, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Frederick, Maryland, United States of America

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  • Ying-Huang Tsai,

    Affiliations: Department of Pulmonary and Critical Care, Chang Gung Memorial Hospital, Taiwan, Department of Respiratory Care, Chang Gung University, Taiwan

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  • Young Tae Kim,

    Affiliations: Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea, Department of Thoracic and Cardiovascular Surgery, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea

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  • Wong-Ho Chow,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Huan Guo,

    Affiliation: Institute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, China

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  • Wen-Chang Wang,

    Affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan

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  • Sook Whan Sung,

    Affiliations: Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea, Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Geongi-do, Republic of Korea

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  • Zhibin Hu,

    Affiliation: Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China

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  • Kuan-Yu Chen,

    Affiliation: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

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  • Joo Hyun Kim,

    Affiliation: Department of Thoracic and Cardiovascular Surgery, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea

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  • Ying Chen,

    Affiliation: Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore

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  • Liming Huang,

    Affiliation: Departments of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

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  • Kyoung-Mu Lee,

    Affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

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  • Yen-Li Lo,

    Affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan

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  • Yu-Tang Gao,

    Affiliation: Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China

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  • Jin Hee Kim,

    Affiliations: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea

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  • Li Liu,

    Affiliation: Institute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, China

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  • Ming-Shyan Huang,

    Affiliation: Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

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  • Tae Hoon Jung,

    Affiliation: Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

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  • Guangfu Jin,

    Affiliation: Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China

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  • Neil Caporaso,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Dianke Yu,

    Affiliation: Departments of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

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  • Chang Ho Kim,

    Affiliation: Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

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  • Wu-Chou Su,

    Affiliation: Department of Internal Medicine, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan

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  • Xiao-Ou Shu,

    Affiliation: Department of Medicine, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Ping Xu,

    Affiliation: Institute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, China

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  • In-San Kim,

    Affiliation: Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

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  • Yuh-Min Chen,

    Affiliations: Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan, School of Medicine, National Yang-Ming University, Taipei, Taiwan

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  • Hongxia Ma,

    Affiliation: Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China

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  • Min Shen,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Sung Ick Cha,

    Affiliation: Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

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  • Wen Tan,

    Affiliation: Departments of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

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  • Chin-Hao Chang,

    Affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan

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  • Jae Sook Sung,

    Affiliations: Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea, Department of Internal Medicine and Division of Brain, Korea University College of Medicine, Seoul, Republic of Korea

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  • Mingfeng Zhang,

    Affiliation: Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China

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  • Tsung-Ying Yang,

    Affiliation: Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

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  • Kyong Hwa Park,

    Affiliations: Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea, Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea

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  • Jeff Yuenger,

    Affiliations: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America, Core Genotyping Facility, Advanced Technology Program, Science Applications International Corporation-Frederick, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Frederick, Maryland, United States of America

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  • Chih-Liang Wang,

    Affiliation: Department of Pulmonary and Critical Care, Chang Gung Memorial Hospital, Taiwan

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  • Jeong-Seon Ryu,

    Affiliation: Department of Internal Medicine, Inha University College of Medicine, Incheon, Republic of Korea

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  • Yongbing Xiang,

    Affiliation: Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China

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  • Qifei Deng,

    Affiliation: Institute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, China

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  • Amy Hutchinson,

    Affiliations: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America, Core Genotyping Facility, Advanced Technology Program, Science Applications International Corporation-Frederick, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Frederick, Maryland, United States of America

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  • Jun Suk Kim,

    Affiliations: Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea, Department of Internal Medicine and Division of Brain, Korea University College of Medicine, Seoul, Republic of Korea, Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea

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  • Qiuyin Cai,

    Affiliation: Department of Medicine, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Maria Teresa Landi,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Chong-Jen Yu,

    Affiliation: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

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  • Ju-Yeon Park,

    Affiliation: Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea

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  • Margaret Tucker,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Jen-Yu Hung,

    Affiliation: Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

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  • Chien-Chung Lin,

    Affiliation: Department of Internal Medicine, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan

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  • Reury-Perng Perng,

    Affiliation: Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan

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  • Paolo Boffetta,

    Affiliation: International Agency for Research on Cancer, Lyon, France

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  • Chih-Yi Chen,

    Affiliation: Cancer Center, China Medical University Hospital, Taipei, Taiwan

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  • Kun-Chieh Chen,

    Affiliation: Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

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  • Shi-Yi Yang,

    Affiliation: Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan

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  • Chi-Yuan Hu,

    Affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan

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  • Chung-Kai Chang,

    Affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan

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  • Joseph F. Fraumeni Jr,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Stephen Chanock ,

    Affiliations: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America, Core Genotyping Facility, Advanced Technology Program, Science Applications International Corporation-Frederick, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Frederick, Maryland, United States of America, Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

    These authors were joint senior authors on this work.

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  • Pan-Chyr Yang ,

    Affiliation: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

    These authors were joint senior authors on this work.

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  • Nathaniel Rothman ,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

    These authors were joint senior authors on this work.

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  • Dongxin Lin

    Affiliation: Departments of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

    These authors were joint senior authors on this work.

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  • Published: August 05, 2010
  • DOI: 10.1371/journal.pgen.1001051

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