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Research Article

Ablation of Whirlin Long Isoform Disrupts the USH2 Protein Complex and Causes Vision and Hearing Loss

  • Jun Yang mail,

    tiansen.li@nih.gov (TL); jun.yang@hsc.utah.edu (JY)

    Affiliation: The Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

    Current address: Department of Ophthalmology and Visual Sciences, Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah, United States of America

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  • Xiaoqing Liu,

    Affiliation: The Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

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  • Yun Zhao,

    Affiliation: The Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

    Current address: Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Science, Shanghai, China

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  • Michael Adamian,

    Affiliation: The Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

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  • Basil Pawlyk,

    Affiliation: The Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

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  • Xun Sun,

    Affiliation: The Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

    Current address: Neurobiology, Neurodegeneration & Repair Laboratory, National Eye Institute, Bethesda, Maryland, United States of America

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  • D. Randy McMillan,

    Affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • M. Charles Liberman,

    Affiliation: Department of Otology and Laryngology, Harvard Medical School and Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

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  • Tiansen Li mail

    tiansen.li@nih.gov (TL); jun.yang@hsc.utah.edu (JY)

    Affiliation: The Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

    Current address: Neurobiology, Neurodegeneration & Repair Laboratory, National Eye Institute, Bethesda, Maryland, United States of America

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  • Published: May 20, 2010
  • DOI: 10.1371/journal.pgen.1000955

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