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Research Article

Modeling of Environmental Effects in Genome-Wide Association Studies Identifies SLC2A2 and HP as Novel Loci Influencing Serum Cholesterol Levels

  • Wilmar Igl mail,

    wilmar.igl@genpat.uu.se

    Affiliation: Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden

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  • Åsa Johansson,

    Affiliation: Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden

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  • James F. Wilson,

    Affiliation: Centre for Population Health Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Sarah H. Wild,

    Affiliation: Centre for Population Health Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Ozren Polašek,

    Affiliation: Andrija Štampar School of Public Health, Faculty of Medicine, University of Zagreb, Zagreb, Croatia

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  • Caroline Hayward,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Veronique Vitart,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Nicholas Hastie,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Pavao Rudan,

    Affiliation: Institute for Anthropological Research, Zagreb, Croatia

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  • Carsten Gnewuch,

    Affiliation: Institute for Clinical Chemistry and Laboratory Medicine, Regensburg University Medical Center, Regensburg, Germany

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  • Gerd Schmitz,

    Affiliation: Institute for Clinical Chemistry and Laboratory Medicine, Regensburg University Medical Center, Regensburg, Germany

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  • Thomas Meitinger,

    Affiliation: Helmholtz Zentrum München, GmbH, Neuherberg, Munich, Germany

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  • Peter P. Pramstaller,

    Affiliations: Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Institute of Genetic Medicine, University of Lübeck, Lübeck, Germany, Department of Neurology, General Central Hospital, Bolzano, Italy, Department of Neurology, University of Lübeck, Lübeck, Germany

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  • Andrew A. Hicks,

    Affiliation: Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy

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  • Ben A. Oostra,

    Affiliation: Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Cornelia M. van Duijn,

    Affiliation: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Igor Rudan,

    Affiliations: Centre for Population Health Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom, Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia

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  • Alan Wright,

    Affiliation: Centre for Population Health Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Harry Campbell,

    Affiliation: Centre for Population Health Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Ulf Gyllensten,

    Affiliation: Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden

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  • EUROSPAN Consortium
  • Published: January 08, 2010
  • DOI: 10.1371/journal.pgen.1000798

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