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Research Article

NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium

  • Nancy L. Heard-Costa equal contributor,

    equal contributor Contributed equally to this work with: Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa

    Affiliation: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • M. Carola Zillikens equal contributor,

    equal contributor Contributed equally to this work with: Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa

    Affiliation: Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

    X
  • Keri L. Monda equal contributor,

    equal contributor Contributed equally to this work with: Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa

    Affiliation: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Åsa Johansson equal contributor,

    equal contributor Contributed equally to this work with: Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa

    Affiliation: Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden

    X
  • Tamara B. Harris equal contributor,

    equal contributor Contributed equally to this work with: Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa

    Affiliation: Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

    X
  • Mao Fu equal contributor,

    equal contributor Contributed equally to this work with: Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa

    Affiliation: Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Talin Haritunians equal contributor,

    equal contributor Contributed equally to this work with: Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa

    Affiliation: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

    X
  • Mary F. Feitosa equal contributor,

    equal contributor Contributed equally to this work with: Nancy L. Heard-Costa, M. Carola Zillikens, Keri L. Monda, Åsa Johansson, Tamara B. Harris, Mao Fu, Talin Haritunians, Mary F. Feitosa

    Affiliation: Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Thor Aspelund,

    Affiliations: Heart Preventive Clinic and Research Institute, Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

    X
  • Gudny Eiriksdottir,

    Affiliation: Heart Preventive Clinic and Research Institute, Icelandic Heart Association, Kopavogur, Iceland

    X
  • Melissa Garcia,

    Affiliation: Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

    X
  • Lenore J. Launer,

    Affiliation: Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

    X
  • Albert V. Smith,

    Affiliation: Heart Preventive Clinic and Research Institute, Icelandic Heart Association, Kopavogur, Iceland

    X
  • Braxton D. Mitchell,

    Affiliation: Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Patrick F. McArdle,

    Affiliation: Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Alan R. Shuldiner,

    Affiliation: Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Suzette J. Bielinski,

    Affiliation: Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • Eric Boerwinkle,

    Affiliation: Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, United States of America

    X
  • Fred Brancati,

    Affiliation: Department of Medicine and Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Ellen W. Demerath,

    Affiliation: Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, United States of America

    X
  • James S. Pankow,

    Affiliation: Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, United States of America

    X
  • Alice M. Arnold,

    Affiliation: Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

    X
  • Yii-Der Ida Chen,

    Affiliation: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

    X
  • Nicole L. Glazer,

    Affiliation: Department of Internal Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • Barbara McKnight,

    Affiliation: Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

    X
  • Bruce M. Psaty,

    Affiliation: Department of Epidemiology, Medicine, & Health Services, University of Washington, Seattle, Washington, United States of America

    X
  • Jerome I. Rotter,

    Affiliation: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

    X
  • Najaf Amin,

    Affiliation: Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Harry Campbell,

    Affiliation: Department of Public Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom

    X
  • Ulf Gyllensten,

    Affiliation: Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden

    X
  • Cristian Pattaro,

    Affiliation: Institute of Genetic Medicine, European Academy Bozen/Bolzano,Bolzano, Italy

    X
  • Peter P. Pramstaller,

    Affiliations: Institute of Genetic Medicine, European Academy Bozen/Bolzano,Bolzano, Italy, Department of Neurology, University of Lübeck, Lübeck, Germany, Department of Neurology, Central Regional Hospital, Bolzano, Italy

    X
  • Igor Rudan,

    Affiliations: Department of Public Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom, Croatian Centre for Global Health, University of Split Medical School, Split, Croatia, Institute for Clinical Medical Research, University Hospital “Sestre Milosrdnice,” Zagreb, Croatia

    X
  • Maksim Struchalin,

    Affiliation: Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Veronique Vitart,

    Affiliation: Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh, Scotland, United Kingdom

    X
  • Xiaoyi Gao,

    Affiliation: Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Aldi Kraja,

    Affiliation: Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Michael A. Province,

    Affiliation: Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Qunyuan Zhang,

    Affiliation: Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

    X
  • Larry D. Atwood,

    Affiliation: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • Josée Dupuis,

    Affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Joel N. Hirschhorn,

    Affiliation: Program in Genomics and Divisions of Endocrinology and Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Cashell E. Jaquish,

    Affiliation: Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

    X
  • Christopher J. O'Donnell,

    Affiliation: Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America

    X
  • Ramachandran S. Vasan,

    Affiliations: Boston University School of Medicine, Boston, Massachusetts, United States of America, The Framingham Heart Study, Framingham, Massachusetts, United States of America

    X
  • Charles C. White,

    Affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

    X
  • Yurii S. Aulchenko,

    Affiliation: Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Karol Estrada,

    Affiliation: Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

    X
  • Albert Hofman,

    Affiliation: Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Fernando Rivadeneira,

    Affiliations: Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • André G. Uitterlinden,

    Affiliations: Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Jacqueline C. M. Witteman,

    Affiliation: Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Ben A. Oostra ,

    Affiliation: Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

    These authors are joint senior authors on this work.

    X
  • Robert C. Kaplan ,

    Affiliation: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America

    These authors are joint senior authors on this work.

    X
  • Vilmundur Gudnason ,

    Affiliations: Heart Preventive Clinic and Research Institute, Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

    These authors are joint senior authors on this work.

    X
  • Jeffrey R. O'Connell ,

    Affiliation: Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    These authors are joint senior authors on this work.

    X
  • Ingrid B. Borecki ,

    Affiliation: Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

    These authors are joint senior authors on this work.

    X
  • Cornelia M. van Duijn ,

    Affiliation: Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands

    These authors are joint senior authors on this work.

    X
  • L. Adrienne Cupples ,

    Affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

    These authors are joint senior authors on this work.

    X
  • Caroline S. Fox mail,

    foxca@nhlbi.nih.gov (CSF); knorth@email.unc.edu (KEN)

    Affiliations: Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America, Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

    These authors are joint senior authors on this work.

    X
  • Kari E. North mail

    foxca@nhlbi.nih.gov (CSF); knorth@email.unc.edu (KEN)

    Affiliation: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    These authors are joint senior authors on this work.

    X
  • Published: June 26, 2009
  • DOI: 10.1371/journal.pgen.1000539

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