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Research Article

CTCF cis-Regulates Trinucleotide Repeat Instability in an Epigenetic Manner: A Novel Basis for Mutational Hot Spot Determination

  • Randell T. Libby equal contributor,

    equal contributor Contributed equally to this work with: Randell T. Libby, Katharine A. Hagerman

    Affiliation: Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, United States of America

    X
  • Katharine A. Hagerman equal contributor,

    equal contributor Contributed equally to this work with: Randell T. Libby, Katharine A. Hagerman

    Affiliations: Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

    X
  • Victor V. Pineda,

    Affiliation: Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, United States of America

    X
  • Rachel Lau,

    Affiliation: Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

    X
  • Diane H. Cho,

    Affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Sandy L. Baccam,

    Affiliation: Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, United States of America

    X
  • Michelle M. Axford,

    Affiliations: Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

    X
  • John D. Cleary,

    Affiliations: Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

    X
  • James M. Moore,

    Affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Bryce L. Sopher,

    Affiliation: Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, United States of America

    X
  • Stephen J. Tapscott,

    Affiliations: Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Neurology (Neurogenetics), University of Washington Medical Center, Seattle, Washington, United States of America

    X
  • Galina N. Filippova,

    Affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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  • Christopher E. Pearson,

    Affiliations: Program of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

    X
  • Albert R. La Spada mail

    laspada@u.washington.edu

    Affiliations: Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, United States of America, Department of Neurology (Neurogenetics), University of Washington Medical Center, Seattle, Washington, United States of America, Department of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, Washington, United States of America, Center for Neurogenetics & Neurotherapeutics, University of Washington Medical Center, Seattle, Washington, United States of America

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  • Published: November 14, 2008
  • DOI: 10.1371/journal.pgen.1000257

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