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Research Article

Unbiased Gene Expression Analysis Implicates the huntingtin Polyglutamine Tract in Extra-mitochondrial Energy Metabolism

  • Jong-Min Lee,

    Affiliation: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Elena V Ivanova,

    Affiliation: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    ยค Current address: Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Ihn Sik Seong,

    Affiliation: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Tanya Cashorali,

    Affiliation: Children's Hospital Informatics Program, Children's Hospital, Boston, Massachusetts, United States of America

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  • Isaac Kohane,

    Affiliation: Children's Hospital Informatics Program, Children's Hospital, Boston, Massachusetts, United States of America

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  • James F Gusella,

    Affiliations: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Huntington's Disease Society of America Coalition for the Cure Mitochondria and Energy Metabolism Team, New York, New York, United States of America

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  • Marcy E MacDonald mail

    To whom correspondence should be addressed. E-mail: macdonam@helix.mgh.harvard.edu

    Affiliations: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Huntington's Disease Society of America Coalition for the Cure Mitochondria and Energy Metabolism Team, New York, New York, United States of America

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  • Published: August 17, 2007
  • DOI: 10.1371/journal.pgen.0030135

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