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Research Article

Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits

  • Angelo Scuteri equal contributor,

    equal contributor Contributed equally to this work with: Angelo Scuteri, Serena Sanna

    Affiliations: Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

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  • Serena Sanna equal contributor,

    equal contributor Contributed equally to this work with: Angelo Scuteri, Serena Sanna

    Affiliations: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America, Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Wei-Min Chen,

    Affiliation: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Manuela Uda,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Giuseppe Albai,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • James Strait,

    Affiliation: Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

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  • Samer Najjar,

    Affiliation: Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

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  • Ramaiah Nagaraja,

    Affiliation: Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

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  • Marco Orrú,

    Affiliations: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy, Unità Operativa Semplice Cardiologia, Divisione di Medicina, Presidio Ospedaliero Santa Barbara, Iglesias, Italy

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  • Gianluca Usala,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Mariano Dei,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Sandra Lai,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Andrea Maschio,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Fabio Busonero,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Antonella Mulas,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Georg B Ehret,

    Affiliation: Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Ashley A Fink,

    Affiliation: Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Alan B Weder,

    Affiliation: Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America

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  • Richard S Cooper,

    Affiliation: Department of Preventive Medicine and Epidemiology, Loyola Stritch School of Medicine, Chicago, Illinois, United States of America

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  • Pilar Galan,

    Affiliations: Institut Scientifique et Technique de la Nutrition et de l'Alimentation, Paris, France, INSERM, U557 (UMR INSERM/INRA/CNAM), Paris, France

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  • Aravinda Chakravarti,

    Affiliation: Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • David Schlessinger mail,

    To whom correspondence should be addressed. E-mail: schlessingerd@grc.nia.nih.gov (DS); goncalo@umich.edu (GRA)

    Affiliation: Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

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  • Antonio Cao,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Edward Lakatta,

    Affiliation: Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

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  • Gonçalo R Abecasis mail

    To whom correspondence should be addressed. E-mail: schlessingerd@grc.nia.nih.gov (DS); goncalo@umich.edu (GRA)

    Affiliation: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Published: July 20, 2007
  • DOI: 10.1371/journal.pgen.0030115

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