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Research Article

PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism

  • Gema Medina-Gomez,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Sarah L Gray,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Laxman Yetukuri,

    Affiliation: Technical Research Centre of Finland (VTT), Espoo, Finland

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  • Kenju Shimomura,

    Affiliation: University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom

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  • Sam Virtue,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Mark Campbell,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • R. Keira Curtis,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Mercedes Jimenez-Linan,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Margaret Blount,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Giles S. H Yeo,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Miguel Lopez,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Tuulikki Seppänen-Laakso,

    Affiliation: Technical Research Centre of Finland (VTT), Espoo, Finland

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  • Frances M Ashcroft,

    Affiliation: University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom

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  • Matej Orešič,

    Affiliation: Technical Research Centre of Finland (VTT), Espoo, Finland

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  • Antonio Vidal-Puig mail

    To whom correspondence should be addressed. E-mail: ajv22@cam.ac.uk

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Published: April 27, 2007
  • DOI: 10.1371/journal.pgen.0030064

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