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Research Article

Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4

  • Cécile Libioulle,

    Affiliation: Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium

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  • Edouard Louis,

    Affiliation: Unit of Hepatology and Gastroenterology, Department of Clinical Sciences, GIGA-R, Faculty of Medicine, and CHU de Liège, University of Liège, Liège, Belgium

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  • Sarah Hansoul,

    Affiliation: Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium

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  • Cynthia Sandor,

    Affiliation: Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium

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  • Frédéric Farnir,

    Affiliation: Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium

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  • Denis Franchimont,

    Affiliation: Department of Gastroenterology, Erasmus Hospital, Free University of Brussels, Brussels, Belgium

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  • Séverine Vermeire,

    Affiliation: Department of Gastroenterology, University Hospital Leuven, Leuven, Belgium

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  • Olivier Dewit,

    Affiliation: Department of Gastroenterology, Clinique Universitaire St Luc, UCL, Brussels, Belgium

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  • Martine de Vos,

    Affiliation: Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium

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  • Anna Dixon,

    Affiliation: National Heart and Lung Institute, Imperial College London, England

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  • Bruno Demarche,

    Affiliation: Unit of Bioinformatics, GIGA-R and Institut Montefiore, University of Liège, Liège, Belgium

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  • Ivo Gut,

    Affiliation: Centre National de Génotypage, Evry, France

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  • Simon Heath,

    Affiliation: Centre National de Génotypage, Evry, France

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  • Mario Foglio,

    Affiliation: Centre National de Génotypage, Evry, France

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  • Liming Liang,

    Affiliation: Centre for Statistical Genetics, Department of Biostatistics, Ann Arbor, Michigan, United States

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  • Debby Laukens,

    Affiliation: Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium

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  • Myriam Mni,

    Affiliation: Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium

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  • Diana Zelenika,

    Affiliation: Centre National de Génotypage, Evry, France

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  • André Van Gossum,

    Affiliation: Department of Gastroenterology, Erasmus Hospital, Free University of Brussels, Brussels, Belgium

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  • Paul Rutgeerts,

    Affiliation: Department of Gastroenterology, University Hospital Leuven, Leuven, Belgium

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  • Jacques Belaiche,

    Affiliation: Unit of Hepatology and Gastroenterology, Department of Clinical Sciences, GIGA-R, Faculty of Medicine, and CHU de Liège, University of Liège, Liège, Belgium

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  • Mark Lathrop,

    Affiliation: Centre National de Génotypage, Evry, France

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  • Michel Georges mail

    To whom correspondence should be addressed. E-mail: michel.georges@ulg.ac.be

    Affiliation: Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium

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  • Published: April 20, 2007
  • DOI: 10.1371/journal.pgen.0030058

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