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Research Article

A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas

  • Patricia L. M Dahia mail,

    To whom correspondence should be addressed. E-mail: Patricia_Dahia@dfci.harvard.edu

    Affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

    ¤Current address: Department of Medicine and Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America

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  • Ken N Ross,

    Affiliation: Broad Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Matthew E Wright,

    Affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • César Y Hayashida,

    Affiliation: University of São Paulo School of Medicine, São Paulo, Brazil

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  • Sandro Santagata,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Marta Barontini,

    Affiliation: Center of Endocrine Investigations, Hospital de Niños R. Gutierrez, Buenos Aires, Argentina

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  • Andrew L Kung,

    Affiliation: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Gabriela Sanso,

    Affiliation: Center of Endocrine Investigations, Hospital de Niños R. Gutierrez, Buenos Aires, Argentina

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  • James F Powers,

    Affiliation: Tufts–New England Medical Center, Boston, Massachusetts, United States of America

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  • Arthur S Tischler,

    Affiliation: Tufts–New England Medical Center, Boston, Massachusetts, United States of America

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  • Richard Hodin,

    Affiliation: Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Shannon Heitritter,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Francis Moore Jr.,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Robert Dluhy,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Julie Ann Sosa,

    Affiliation: Yale University, New Haven, Connecticut, United States of America

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  • I. Tolgay Ocal,

    Affiliation: Yale University, New Haven, Connecticut, United States of America

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  • Diana E Benn,

    Affiliation: Royal North Shore Hospital and Kolling Institute of Medical Research, University of Sydney, Australia

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  • Deborah J Marsh,

    Affiliation: Royal North Shore Hospital and Kolling Institute of Medical Research, University of Sydney, Australia

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  • Bruce G Robinson,

    Affiliation: Royal North Shore Hospital and Kolling Institute of Medical Research, University of Sydney, Australia

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  • Katherine Schneider,

    Affiliation: Division of Population Sciences, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Judy Garber,

    Affiliation: Division of Population Sciences, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Seth M Arum,

    Affiliation: Boston Medical Center, Boston, Massachusetts, United States of America

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  • Márta Korbonits,

    Affiliation: St. Bartholomew's Hospital, London, United Kingdom

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  • Ashley Grossman,

    Affiliation: St. Bartholomew's Hospital, London, United Kingdom

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  • Pascal Pigny,

    Affiliation: Regional University Hospital, Lille, France

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  • Sérgio P. A Toledo,

    Affiliation: University of São Paulo School of Medicine, São Paulo, Brazil

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  • Vania Nosé,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Cheng Li,

    Affiliation: Department of Biostatistical Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Charles D Stiles

    Affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: July 25, 2005
  • DOI: 10.1371/journal.pgen.0010008

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