Journal Archive
This archive contains links to the full-text of all issues of PLoS Genetics.
Current Issue
About This Image
Necrotic protein uptake in garland cells.The garland cells are one of two groups of athrocytes in Drosophila in which extracellular serpin-family inhibitors involved in the innate immune response are taken up and degraded (see Soukup et al., 10.1371/journal.pgen.1000532). The image shows a broken ring of garland cells encircling the oesophagus above the proventriculus (Z-series reconstruction). Endocytosis has been frozen using a Dynamints mutation, allowing Necrotic (red) to be detected within the cortical labyrinthine channels of the garland cells. In a normal fly, Necrotic is endocytosed via the LpR1 trafficking receptor, processed through multi-vesicular bodies, and delivered to the lysosome for degradation.
Image Credit: Picture taken by Dr. Sandra Soukup in the laboratory of Dr. David Gubb (CICbioGUNE Institute, Derio, Spain).