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Chromosome fusion occurring within a colony of Vibrio cholerae.In their study, Val et al. show how reorganizing the genome of bacteria in a deliberate manner can help solve biological issues. In this image, blue sectors within a colony of the pathogen Vibrio cholerae indicate successful fusion of the two chromosomes to form a synthetic mono-chromosomal strain by directed site-specific recombination. This mono-chromosomal strain was further used to demonstrate that Dam, RctB, and ParA2/ParB2 factors are only essential for chrII maintenance.
Image Credit: Thibault Rouxel and Marie-Eve Val (Institut Pasteur)