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Table of Contents: December 2010

COVER

A mutant fungal fruiting body.

Image Credit: Özgür Bayram and Gerhard Braus
Issue Image

Aspergillus nidulans is a cosmopolitan mold growing with filaments (yellow). During the sexual cycle, two fungal partners form closed fruiting bodies (purple), which are covered by hundreds of globose Hülle cells (brown). In this issue of PLoS Genetics, Bayram et al. show that, in the absence of the regulator LaeA, the number of Hülle cells is drastically reduced and results in the shown small fruiting bodies of only 20% of the normal size. This supports the view that nursing the young fruiting body is a major function of Hülle cells.

Perspective

Review

Cancer and Neurodegeneration: Between the Devil and the Deep Blue Sea

Hélène Plun-Favreau, Patrick A. Lewis, John Hardy, L. Miguel Martins, Nicholas W. Wood

Research Articles

Whole-Genome and Chromosome Evolution Associated with Host Adaptation and Speciation of the Wheat Pathogen Mycosphaerella graminicola

Eva H. Stukenbrock, Frank G. Jørgensen, Marcello Zala, Troels T. Hansen, Bruce A. McDonald, Mikkel H. Schierup

MOS11: A New Component in the mRNA Export Pathway

Hugo Germain, Na Qu, Yu Ti Cheng, EunKyoung Lee, Yan Huang, Oliver Xiaoou Dong, Patrick Gannon, Shuai Huang, Pingtao Ding, Yingzhong Li, Fred Sack, Yuelin Zhang, Xin Li

Thymus-Associated Parathyroid Hormone Has Two Cellular Origins with Distinct Endocrine and Immunological Functions

Zhijie Liu, Alison Farley, Lizhen Chen, Beth J. Kirby, Christopher S. Kovacs, C. Clare Blackburn, Nancy R. Manley

Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles

Robert A. Waterland, Richard Kellermayer, Eleonora Laritsky, Pura Rayco-Solon, R. Alan Harris, Michael Travisano, Wenjuan Zhang, Maria S. Torskaya, Jiexin Zhang, Lanlan Shen, Mark J. Manary, Andrew M. Prentice

Cleavage of Phosphorothioated DNA and Methylated DNA by the Type IV Restriction Endonuclease ScoMcrA

Guang Liu, Hong-Yu Ou, Tao Wang, Li Li, Huarong Tan, Xiufen Zhou, Kumar Rajakumar, Zixin Deng, Xinyi He

Identification of Genes Required for Neural-Specific Glycosylation Using Functional Genomics

Miki Yamamoto-Hino, Yoshimi Kanie, Wakae Awano, Kiyoko F. Aoki-Kinoshita, Hiroyuki Yano, Shoko Nishihara, Hideyuki Okano, Ryu Ueda, Osamu Kanie, Satoshi Goto

A Young Drosophila Duplicate Gene Plays Essential Roles in Spermatogenesis by Regulating Several Y-Linked Male Fertility Genes

Yun Ding, Li Zhao, Shuang Yang, Yu Jiang, Yuan Chen, Ruoping Zhao, Yue Zhang, Guojie Zhang, Yang Dong, Haijing Yu, Qi Zhou, Wen Wang

Genomics Meets Glycomics—The First GWAS Study of Human N-Glycome Identifies HNF1α as a Master Regulator of Plasma Protein Fucosylation

Gordan Lauc, Abdelkader Essafi, Jennifer E. Huffman, Caroline Hayward, Ana Knežević, Jayesh J. Kattla, Ozren Polašek, Olga Gornik, Veronique Vitart, Jodie L. Abrahams, Maja Pučić, Mislav Novokmet, Irma Redžić, Susan Campbell, Sarah H. Wild, Fran Borovečki, Wei Wang, Ivana Kolčić, Lina Zgaga, Ulf Gyllensten, James F. Wilson, Alan F. Wright, Nicholas D. Hastie, Harry Campbell, Pauline M. Rudd, Igor Rudan

A Role for ATF2 in Regulating MITF and Melanoma Development

Meera Shah, Anindita Bhoumik, Vikas Goel, Antimone Dewing, Wolfgang Breitwieser, Harriet Kluger, Stan Krajewski, Maryla Krajewska, Jason DeHart, Eric Lau, David M. Kallenberg, Hyeongnam Jeong, Alexey Eroshkin, Dorothy C. Bennett, Lynda Chin, Marcus Bosenberg, Nic Jones, Ze'ev A. Ronai

Ancestral Regulatory Circuits Governing Ectoderm Patterning Downstream of Nodal and BMP2/4 Revealed by Gene Regulatory Network Analysis in an Echinoderm

Alexandra Saudemont, Emmanuel Haillot, Flavien Mekpoh, Nathalie Bessodes, Magali Quirin, François Lapraz, Véronique Duboc, Eric Röttinger, Ryan Range, Arnaud Oisel, Lydia Besnardeau, Patrick Wincker, Thierry Lepage

Initiator Elements Function to Determine the Activity State of BX-C Enhancers

Carole Iampietro, Maheshwar Gummalla, Annick Mutero, François Karch, Robert K. Maeda

Self-Mating in the Definitive Host Potentiates Clonal Outbreaks of the Apicomplexan Parasites Sarcocystis neurona and Toxoplasma gondii

Jered M. Wendte, Melissa A. Miller, Dyanna M. Lambourn, Spencer L. Magargal, David A. Jessup, Michael E. Grigg

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

Clement T. Y. Chan, Madhu Dyavaiah, Michael S. DeMott, Koli Taghizadeh, Peter C. Dedon, Thomas J. Begley

Functional Comparison of Innate Immune Signaling Pathways in Primates

Luis B. Barreiro, John C. Marioni, Ran Blekhman, Matthew Stephens, Yoav Gilad

Histone H2A C-Terminus Regulates Chromatin Dynamics, Remodeling, and Histone H1 Binding

Christine Vogler, Claudia Huber, Tanja Waldmann, Ramona Ettig, Lora Braun, Annalisa Izzo, Sylvain Daujat, Isabelle Chassignet, Andres Joaquin Lopez-Contreras, Oscar Fernandez-Capetillo, Miroslav Dundr, Karsten Rippe, Gernot Längst, Robert Schneider

Endocytic Sorting and Recycling Require Membrane Phosphatidylserine Asymmetry Maintained by TAT-1/CHAT-1

Baohui Chen, Yue Jiang, Sheng Zeng, Jiacong Yan, Xin Li, Yan Zhang, Wei Zou, Xiaochen Wang

Noisy Splicing Drives mRNA Isoform Diversity in Human Cells

Joseph K. Pickrell, Athma A. Pai, Yoav Gilad, Jonathan K. Pritchard

The C-Terminal Domain of the Bacterial SSB Protein Acts as a DNA Maintenance Hub at Active Chromosome Replication Forks

Audrey Costes, François Lecointe, Stephen McGovern, Sophie Quevillon-Cheruel, Patrice Polard

Investigation and Functional Characterization of Rare Genetic Variants in the Adipose Triglyceride Lipase in a Large Healthy Working Population

Stefan Coassin, Martina Schweiger, Anita Kloss-Brandstätter, Claudia Lamina, Margot Haun, Gertraud Erhart, Bernhard Paulweber, Yusof Rahman, Simon Olpin, Heimo Wolinski, Irina Cornaciu, Rudolf Zechner, Robert Zimmermann, Florian Kronenberg

Histone Deacetylases Suppress CGG Repeat–Induced Neurodegeneration Via Transcriptional Silencing in Models of Fragile X Tremor Ataxia Syndrome

Peter K. Todd, Seok Yoon Oh, Amy Krans, Udai B. Pandey, Nicholas A. Di Prospero, Kyung-Tai Min, J. Paul Taylor, Henry L. Paulson

Genome-Wide Interrogation of Mammalian Stem Cell Fate Determinants by Nested Chromosome Deletions

Simon Fortier, Mélanie Bilodeau, Tara MacRae, Jean-Philippe Laverdure, Valeria Azcoitia, Simon Girard, Jalila Chagraoui, Nancy Ringuette, Josée Hébert, Jana Krosl, Nadine Mayotte, Guy Sauvageau

Continuous and Periodic Expansion of CAG Repeats in Huntington's Disease R6/1 Mice

Linda Møllersen, Alexander D. Rowe, Elisabeth Larsen, Torbjørn Rognes, Arne Klungland

GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells

Eric M. Mendenhall, Richard P. Koche, Thanh Truong, Vicky W. Zhou, Biju Issac, Andrew S. Chi, Manching Ku, Bradley E. Bernstein

Association of Variants at 1q32 and STAT3 with Ankylosing Spondylitis Suggests Genetic Overlap with Crohn's Disease

Patrick Danoy, Karena Pryce, Johanna Hadler, Linda A. Bradbury, Claire Farrar, Jennifer Pointon, Michael Ward, Michael Weisman, John D. Reveille, B. Paul Wordsworth, Millicent A. Stone, Walter P. Maksymowych, Proton Rahman, Dafna Gladman, Robert D. Inman, Matthew A. Brown , Australo-Anglo-American Spondyloarthritis Consortium (TASC), Spondyloarthritis Research Consortium of Canada (SPARCC)

LaeA Control of Velvet Family Regulatory Proteins for Light-Dependent Development and Fungal Cell-Type Specificity

Özlem Sarikaya Bayram, Özgür Bayram, Oliver Valerius, Hee Soo Park, Stefan Irniger, Jennifer Gerke, Min Ni, Kap-Hoon Han, Jae-Hyuk Yu, Gerhard H. Braus

The DNA Damage Response Pathway Contributes to the Stability of Chromosome III Derivatives Lacking Efficient Replicators

James F. Theis, Carmela Irene, Ann Dershowitz, Renee L. Brost, Michael L. Tobin, Fabiana M. di Sanzo, Jian-Ying Wang, Charles Boone, Carol S. Newlon

Competitive Repair by Naturally Dispersed Repetitive DNA during Non-Allelic Homologous Recombination

Margaret L. Hoang, Frederick J. Tan, David C. Lai, Sue E. Celniker, Roger A. Hoskins, Maitreya J. Dunham, Yixian Zheng, Douglas Koshland

The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila

Yuzuru Imai, Tomoko Kanao, Tomoyo Sawada, Yoshito Kobayashi, Yasuhiro Moriwaki, Yosuke Ishida, Kohsuke Takeda, Hidenori Ichijo, Bingwei Lu, Ryosuke Takahashi

Identification of Y-Box Binding Protein 1 As a Core Regulator of MEK/ERK Pathway-Dependent Gene Signatures in Colorectal Cancer Cells

Karsten Jürchott, Ralf-Jürgen Kuban, Till Krech, Nils Blüthgen, Ulrike Stein, Wolfgang Walther, Christian Friese, Szymon M. Kiełbasa, Ute Ungethüm, Per Lund, Thomas Knösel, Wolfgang Kemmner, Markus Morkel, Johannes Fritzmann, Peter M. Schlag, Walter Birchmeier, Tammo Krueger, Silke Sperling, Christine Sers, Hans-Dieter Royer, Hanspeter Herzel, Reinhold Schäfer

Role of Individual Subunits of the Neurospora crassa CSN Complex in Regulation of Deneddylation and Stability of Cullin Proteins

Jiyong Wang, Qiwen Hu, Huijie Chen, Zhipeng Zhou, Weihua Li, Ying Wang, Shaojie Li, Qun He

Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk

Christin E. Burd, William R. Jeck, Yan Liu, Hanna K. Sanoff, Zefeng Wang, Norman E. Sharpless