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Table of Contents: October 2008

Issue Image

The rate of mutation in a region of the mitochondrial genome of the Adélie penguin was calculated by comparing DNA from a large number of mothers to that of their chicks. To calculate the rate of evolution, DNA was extracted from ancient bones of Adélie penguins and compared to that of present day individuals (see Millar et al., doi:10.1371/journal.pgen.1000209). The bones, which were up to 37,000 years old, were found under present day colonies. The rate of mutation and evolution in Adélie penguins are similar; however, both appear to be proceeding faster than predicted.

Image Credit: Photo of an Adélie penguin adult and its two chicks by Emeritus Professor Euan Young, Auckland University.

Interview

Perspectives

Leaving the Past Behind

E. Jean Finnegan, Emma Whitelaw

Genetical Genomics: Spotlight on QTL Hotspots

Rainer Breitling, Yang Li, Bruno M. Tesson, Jingyuan Fu, Chunlei Wu, Tim Wiltshire, Alice Gerrits, Leonid V. Bystrykh, Gerald de Haan, Andrew I. Su, Ritsert C. Jansen

Research Articles

The Novel Mouse Mutation Oblivion Inactivates the PMCA2 Pump and Causes Progressive Hearing Loss

Sarah L. Spiden, Mario Bortolozzi, Francesca Di Leva, Martin Hrabé de Angelis, Helmut Fuchs, Dmitry Lim, Saida Ortolano, Neil J. Ingham, Marisa Brini, Ernesto Carafoli, Fabio Mammano, Karen P. Steel

Genetic and Linguistic Coevolution in Northern Island Melanesia

Keith Hunley, Michael Dunn, Eva Lindström, Ger Reesink, Angela Terrill, Meghan E. Healy, George Koki, Françoise R. Friedlaender, Jonathan S. Friedlaender

Mutation of the Zebrafish Nucleoporin elys Sensitizes Tissue Progenitors to Replication Stress

Gangarao Davuluri, Weilong Gong, Shamila Yusuff, Kristin Lorent, Manimegalai Muthumani, Amy C. Dolan, Michael Pack

Essential Role of Chromatin Remodeling Protein Bptf in Early Mouse Embryos and Embryonic Stem Cells

Joseph Landry, Alexei A. Sharov, Yulan Piao, Lioudmila V. Sharova, Hua Xiao, Eileen Southon, Jennifer Matta, Lino Tessarollo, Ying E. Zhang, Minoru S. H. Ko, Michael R. Kuehn, Terry P. Yamaguchi, Carl Wu

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

Manching Ku, Richard P. Koche, Esther Rheinbay, Eric M. Mendenhall, Mitsuhiro Endoh, Tarjei S. Mikkelsen, Aviva Presser, Chad Nusbaum, Xiaohui Xie, Andrew S. Chi, Mazhar Adli, Simon Kasif, Leon M. Ptaszek, Chad A. Cowan, Eric S. Lander, Haruhiko Koseki, Bradley E. Bernstein

Adaptive Copy Number Evolution in Malaria Parasites

Shalini Nair, Becky Miller, Marion Barends, Anchalee Jaidee, Jigar Patel, Mayfong Mayxay, Paul Newton, François Nosten, Michael T. Ferdig, Tim J. C. Anderson

Modifier Effects between Regulatory and Protein-Coding Variation

Antigone S. Dimas, Barbara E. Stranger, Claude Beazley, Robert D. Finn, Catherine E. Ingle, Matthew S. Forrest, Matthew E. Ritchie, Panos Deloukas, Simon Tavaré, Emmanouil T. Dermitzakis

The Anticonvulsant Ethosuximide Disrupts Sensory Function to Extend C. elegans Lifespan

James J. Collins, Kimberley Evason, Christopher L. Pickett, Daniel L. Schneider, Kerry Kornfeld

Predicting Unobserved Phenotypes for Complex Traits from Whole-Genome SNP Data

Sang Hong Lee, Julius H. J. van der Werf, Ben J. Hayes, Michael E. Goddard, Peter M. Visscher

Evolution and Dynamics of Regulatory Architectures Controlling Polymyxin B Resistance in Enteric Bacteria

Alexander Y. Mitrophanov, Mollie W. Jewett, Tricia J. Hadley, Eduardo A. Groisman

Genetic Networks Controlling Structural Outcome of Glucosinolate Activation across Development

Adam M. Wentzell, Ian Boeye, Zhiyong Zhang, Daniel J. Kliebenstein

Two Pathways Recruit Telomerase to Saccharomyces cerevisiae Telomeres

Angela Chan, Jean-Baptiste Boulé, Virginia A. Zakian

Mechanisms Underlying Hypoxia Tolerance in Drosophila melanogaster: hairy as a Metabolic Switch

Dan Zhou, Jin Xue, James C. K. Lai, Nicholas J. Schork, Kevin P. White, Gabriel G. Haddad

Diverse Splicing Patterns of Exonized Alu Elements in Human Tissues

Lan Lin, Shihao Shen, Anne Tye, James J. Cai, Peng Jiang, Beverly L. Davidson, Yi Xing

High-Resolution Mapping of Expression-QTLs Yields Insight into Human Gene Regulation

Jean-Baptiste Veyrieras, Sridhar Kudaravalli, Su Yeon Kim, Emmanouil T. Dermitzakis, Yoav Gilad, Matthew Stephens, Jonathan K. Pritchard

Cooperation of Sumoylated Chromosomal Proteins in rDNA Maintenance

Yoshimitsu Takahashi, Stanimir Dulev, Xianpeng Liu, Natalie Jasmin Hiller, Xiaolan Zhao, Alexander Strunnikov

A Position Effect on the Heritability of Epigenetic Silencing

Jaswinder Singh, Michael Freeling, Damon Lisch

Genetic Association and Expression Studies Indicate a Role of Toll-Like Receptor 8 in Pulmonary Tuberculosis

Sonia Davila, Martin L. Hibberd, Ranjeeta Hari Dass, Hazel E. E. Wong, Edhyana Sahiratmadja, Carine Bonnard, Bachti Alisjahbana, Jeffrey S. Szeszko, Yanina Balabanova, Francis Drobniewski, Reinout van Crevel, Esther van de Vosse, Sergey Nejentsev, Tom H. M. Ottenhoff, Mark Seielstad

Identification and Replication of Three Novel Myopia Common Susceptibility Gene Loci on Chromosome 3q26 using Linkage and Linkage Disequilibrium Mapping

Toby Andrew, Nikolas Maniatis, Francis Carbonaro, S. H. Melissa Liew, Winston Lau, Tim D. Spector, Christopher J. Hammond

Zebrafish eda and edar Mutants Reveal Conserved and Ancestral Roles of Ectodysplasin Signaling in Vertebrates

Matthew P. Harris, Nicolas Rohner, Heinz Schwarz, Simon Perathoner, Peter Konstantinidis, Christiane Nüsslein-Volhard

A Myo6 Mutation Destroys Coordination between the Myosin Heads, Revealing New Functions of Myosin VI in the Stereocilia of Mammalian Inner Ear Hair Cells

Ronna Hertzano, Ella Shalit, Agnieszka K. Rzadzinska, Amiel A. Dror, Lin Song, Uri Ron, Joshua T. Tan, Alina Starovolsky Shitrit, Helmut Fuchs, Tama Hasson, Nir Ben-Tal, H. Lee Sweeney, Martin Hrabe de Angelis, Karen P. Steel, Karen B. Avraham

Mutability and Importance of a Hypermutable Cell Subpopulation that Produces Stress-Induced Mutants in Escherichia coli

Caleb Gonzalez, Lilach Hadany, Rebecca G. Ponder, Mellanie Price, P. J. Hastings, Susan M. Rosenberg

Mutation and Evolutionary Rates in Adélie Penguins from the Antarctic

Craig D. Millar, Andrew Dodd, Jennifer Anderson, Gillian C. Gibb, Peter A. Ritchie, Carlo Baroni, Michael D. Woodhams, Michael D. Hendy, David M. Lambert

High-Throughput Phenotypic Characterization of Pseudomonas aeruginosa Membrane Transport Genes

Daniel A. Johnson, Sasha G. Tetu, Katherine Phillippy, Joan Chen, Qinghu Ren, Ian T. Paulsen

Time-Lapse Analysis and Mathematical Characterization Elucidate Novel Mechanisms Underlying Muscle Morphogenesis

Chelsi J. Snow, Michelle Goody, Meghan W. Kelly, Emma C. Oster, Robert Jones, Andre Khalil, Clarissa A. Henry