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Table of Contents | September 2008

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Celebrating with Champagne.

The equine coat color dilution Champagne has frequently been confused for and confounded by other dilution phenotypes. The locus responsible for Champagne was mapped by a whole-genome scanning approach, and the causative mutation has subsequently been discovered (see Cook et al., doi:10.1371/journal.pgen.1000195).

Image Credit: Photo is Tennessee Walking Horse "Champagne Watchout," submitted by Nathanael and Jenny Jackson.

Perspective

Chromosome Mechanics and Meiotic Engine Maintenance

Michael E. Dresser

Review

A Review of Family-Based Tests for Linkage Disequilibrium between a Quantitative Trait and a Genetic Marker

Warren J. Ewens, Mingyao Li, Richard S. Spielman

Research Articles

Csm4, in Collaboration with Ndj1, Mediates Telomere-Led Chromosome Dynamics and Recombination during Yeast Meiosis

Jennifer J. Wanat, Keun P. Kim, Romain Koszul, Sarah Zanders, Beth Weiner, Nancy Kleckner, Eric Alani

Csm4-Dependent Telomere Movement on Nuclear Envelope Promotes Meiotic Recombination

Hiromichi Kosaka, Miki Shinohara, Akira Shinohara

Sex-Specific Genetic Structure and Social Organization in Central Asia: Insights from a Multi-Locus Study

Laure Ségurel, Begoña Martínez-Cruz, Lluis Quintana-Murci, Patricia Balaresque, Myriam Georges, Tatiana Hegay, Almaz Aldashev, Firuza Nasyrova, Mark A. Jobling, Evelyne Heyer, Renaud Vitalis

FtsK-Dependent Dimer Resolution on Multiple Chromosomes in the Pathogen Vibrio cholerae

Marie-Eve Val, Sean P. Kennedy, Meriem El Karoui, Laetitia Bonné, Fabien Chevalier, François-Xavier Barre

Sex-Biased Evolutionary Forces Shape Genomic Patterns of Human Diversity

Michael F. Hammer, Fernando L. Mendez, Murray P. Cox, August E. Woerner, Jeffrey D. Wall

Tracing the Source of Campylobacteriosis

Daniel J. Wilson, Edith Gabriel, Andrew J. H. Leatherbarrow, John Cheesbrough, Steven Gee, Eric Bolton, Andrew Fox, Paul Fearnhead, C. Anthony Hart, Peter J. Diggle

Intronic Alus Influence Alternative Splicing

Galit Lev-Maor, Oren Ram, Eddo Kim, Noa Sela, Amir Goren, Erez Y. Levanon, Gil Ast

A Mouse Model of Harlequin Ichthyosis Delineates a Key Role for Abca12 in Lipid Homeostasis

Ian Smyth, Douglas F. Hacking, Adrienne A. Hilton, Nigora Mukhamedova, Peter J. Meikle, Sarah Ellis, Keith Slattery, Janelle E. Collinge, Carolyn A. de Graaf, Melanie Bahlo, Dmitri Sviridov, Benjamin T. Kile, Douglas J. Hilton

Novel Mutations in TARDBP (TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis

Nicola J. Rutherford, Yong-Jie Zhang, Matt Baker, Jennifer M. Gass, NiCole A. Finch, Ya-Fei Xu, Heather Stewart, Brendan J. Kelley, Karen Kuntz, Richard J. P. Crook, Jemeen Sreedharan, Caroline Vance, Eric Sorenson, Carol Lippa, Eileen H. Bigio, Daniel H. Geschwind, David S. Knopman, Hiroshi Mitsumoto, Ronald C. Petersen, Neil R. Cashman, Mike Hutton, Christopher E. Shaw, Kevin B. Boylan, Bradley Boeve, Neill R. Graff-Radford, Zbigniew K. Wszolek, Richard J. Caselli, Dennis W. Dickson, Ian R. Mackenzie, Leonard Petrucelli, Rosa Rademakers

corona Is Required for Higher-Order Assembly of Transverse Filaments into Full-Length Synaptonemal Complex in Drosophila Oocytes

Scott L. Page, Radhika S. Khetani, Cathleen M. Lake, Rachel J. Nielsen, Jennifer K. Jeffress, William D. Warren, Sharon E. Bickel, R. Scott Hawley

Missense Mutation in Exon 2 of SLC36A1 Responsible for Champagne Dilution in Horses

Deborah Cook, Samantha Brooks, Rebecca Bellone, Ernest Bailey

Screening and Replication using the Same Data Set: Testing Strategies for Family-Based Studies in which All Probands Are Affected

Amy Murphy, Scott T. Weiss, Christoph Lange

An Approximate Bayesian Estimator Suggests Strong, Recurrent Selective Sweeps in Drosophila

Jeffrey D. Jensen, Kevin R. Thornton, Peter Andolfatto

Deletion of the Pluripotency-Associated Tex19.1 Gene Causes Activation of Endogenous Retroviruses and Defective Spermatogenesis in Mice

Rupert Öllinger, Andrew J. Childs, Hannah M. Burgess, Robert M. Speed, Pia R. Lundegaard, Nicola Reynolds, Nicola K. Gray, Howard J. Cooke, Ian R. Adams

Is Mate Choice in Humans MHC-Dependent?

Raphaëlle Chaix, Chen Cao, Peter Donnelly

The Genome of Borrelia recurrentis, the Agent of Deadly Louse-Borne Relapsing Fever, Is a Degraded Subset of Tick-Borne Borrelia duttonii

Magali Lescot, Stéphane Audic, Catherine Robert, Thi Tien Nguyen, Guillaume Blanc, Sally J. Cutler, Patrick Wincker, Arnaud Couloux, Jean-Michel Claverie, Didier Raoult, Michel Drancourt

MUS81 Generates a Subset of MLH1-MLH3–Independent Crossovers in Mammalian Meiosis

J. Kim Holloway, James Booth, Winfried Edelmann, Clare H. McGowan, Paula E. Cohen

The Genomic Distribution and Function of Histone Variant HTZ-1 during C. elegans Embryogenesis

Christina M. Whittle, Karissa N. McClinic, Sevinc Ercan, Xinmin Zhang, Roland D. Green, William G. Kelly, Jason D. Lieb

Human MLH1 Protein Participates in Genomic Damage Checkpoint Signaling in Response to DNA Interstrand Crosslinks, while MSH2 Functions in DNA Repair

Qi Wu, Karen M. Vasquez

The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure

Brendan Jones, Hui Su, Audesh Bhat, Hong Lei, Jeffrey Bajko, Sarah Hevi, Gretchen A. Baltus, Shilpa Kadam, Huili Zhai, Reginald Valdez, Susana Gonzalo, Yi Zhang, En Li, Taiping Chen

Evolution of a New Function by Degenerative Mutation in Cephalochordate Steroid Receptors

Jamie T. Bridgham, Justine E. Brown, Adriana Rodríguez-Marí, Julian M. Catchen, Joseph W. Thornton

Heterokaryon-Based Reprogramming of Human B Lymphocytes for Pluripotency Requires Oct4 but Not Sox2

Carlos F. Pereira, Rémi Terranova, Natalie K. Ryan, Joana Santos, Kelly J. Morris, Wei Cui, Matthias Merkenschlager, Amanda G. Fisher

Identification of Neural Crest and Glial Enhancers at the Mouse Sox10 Locus through Transgenesis in Zebrafish

Anthony Antonellis, Jimmy L. Huynh, Shih-Queen Lee-Lin, Ryan M. Vinton, Gabriel Renaud, Stacie K. Loftus, Gene Elliot, Tyra G. Wolfsberg, Eric D. Green, Andrew S. McCallion, William J. Pavan

Segmental Duplications Arise from Pol32-Dependent Repair of Broken Forks through Two Alternative Replication-Based Mechanisms

Celia Payen, Romain Koszul, Bernard Dujon, Gilles Fischer

Somatic Pairing of Chromosome 19 in Renal Oncocytoma Is Associated with Deregulated ELGN2-Mediated Oxygen-Sensing Response

Julie M. Koeman, Ryan C. Russell, Min-Han Tan, David Petillo, Michael Westphal, Katherine Koelzer, Julie L. Metcalf, Zhongfa Zhang, Daisuke Matsuda, Karl J. Dykema, Heather L. Houseman, Eric J. Kort, Laura L. Furge, Richard J. Kahnoski, Stéphane Richard, Annick Vieillefond, Pamela J. Swiatek, Bin Tean Teh, Michael Ohh, Kyle A. Furge

A Sox10 Expression Screen Identifies an Amino Acid Essential for Erbb3 Function

Kristina Buac, Dawn E. Watkins-Chow, Stacie K. Loftus, Denise M. Larson, Arturo Incao, Gretchen Gibney, William J. Pavan

Stability and Dynamics of Polycomb Target Sites in Drosophila Development

Camilla Kwong, Boris Adryan, Ian Bell, Lisa Meadows, Steven Russell, J. Robert Manak, Robert White

Genetic Modifiers of MeCP2 Function in Drosophila

Holly N. Cukier, Alma M. Perez, Ann L. Collins, Zhaolan Zhou, Huda Y. Zoghbi, Juan Botas

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