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Table of Contents: March 2008

Issue Image

Artistic representation of events occurring during gene silencing in Fragile X mental retardation syndrome (FXS). The FMR1 gene, which is on the X chromosome, colocalizes with a fragile site seen in FXS cells that gives this disorder its name. FXS alleles become associated with SIRT1. SIRT1, a class III histone deacetylase, deacetylates lysine 9 of histone H3 and lysine 16 of histone H4, ultimately leading to chromatin compaction and gene silencing (see Biacsi et al., e1000017).

Image Credit: Image by Dr. Marian L. Miller (Journal-Cover-Art.com).

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Research Articles

Phospholipase C-ε Regulates Epidermal Morphogenesis in Caenorhabditis elegans

Rafael P. Vázquez-Manrique, Anikó I. Nagy, James C. Legg, Olivia A. M. Bales, Sung Ly, Howard A. Baylis

An Essential Role for DYF-11/MIP-T3 in Assembling Functional Intraflagellar Transport Complexes

Chunmei Li, Peter N. Inglis, Carmen C. Leitch, Evgeni Efimenko, Norann A. Zaghloul, Calvin A. Mok, Erica E. Davis, Nathan J. Bialas, Michael P. Healey, Elise Héon, Mei Zhen, Peter Swoboda, Nicholas Katsanis, Michel R. Leroux

Global Chromatin Domain Organization of the Drosophila Genome

Elzo de Wit, Ulrich Braunschweig, Frauke Greil, Harmen J. Bussemaker, Bas van Steensel

Evolution of a Core Gene Network for Skeletogenesis in Chordates

Jochen Hecht, Sigmar Stricker, Ulrike Wiecha, Asita Stiege, Georgia Panopoulou, Lars Podsiadlowski, Albert J. Poustka, Christoph Dieterich, Siegfried Ehrich, Julia Suvorova, Stefan Mundlos, Volkhard Seitz

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

Tjakko J. van Ham, Karen L. Thijssen, Rainer Breitling, Robert M. W. Hofstra, Ronald H. A. Plasterk, Ellen A. A. Nollen

Gene Activation Using FLP Recombinase in C. elegans

M. Wayne Davis, J. Jason Morton, Dana Carroll, Erik M. Jorgensen

An Abundant Evolutionarily Conserved CSB-PiggyBac Fusion Protein Expressed in Cockayne Syndrome

John C. Newman, Arnold D. Bailey, Hua-Ying Fan, Thomas Pavelitz, Alan M. Weiner

Geographic Patterns of Genome Admixture in Latin American Mestizos

Sijia Wang, Nicolas Ray, Winston Rojas, Maria V. Parra, Gabriel Bedoya, Carla Gallo, Giovanni Poletti, Guido Mazzotti, Kim Hill, Ana M. Hurtado, Beatriz Camrena, Humberto Nicolini, William Klitz, Ramiro Barrantes, Julio A. Molina, Nelson B. Freimer, Maria Cátira Bortolini, Francisco M. Salzano, Maria L. Petzl-Erler, Luiza T. Tsuneto, José E. Dipierri, Emma L. Alfaro, Graciela Bailliet, Nestor O. Bianchi, Elena Llop, Francisco Rothhammer, Laurent Excoffier, Andrés Ruiz-Linares

Fine Mapping of the Psoriasis Susceptibility Locus PSORS1 Supports HLA-C as the Susceptibility Gene in the Han Chinese Population

Xing Fan, Sen Yang, Wei Huang, Zhi-Min Wang, Liang-Dan Sun, Yan-Hua Liang, Min Gao, Yue-Qing Ren, Kai-Yue Zhang, Wen-Hui Du, Yu-Jun Shen, Jian-Jun Liu, Xue-Jun Zhang

Recruitment to the Nuclear Periphery Can Alter Expression of Genes in Human Cells

Lee E. Finlan, Duncan Sproul, Inga Thomson, Shelagh Boyle, Elizabeth Kerr, Paul Perry, Bauke Ylstra, Jonathan R. Chubb, Wendy A. Bickmore

New Insights into Human Nondisjunction of Chromosome 21 in Oocytes

Tiffany Renee Oliver, Eleanor Feingold, Kai Yu, Vivian Cheung, Stuart Tinker, Maneesha Yadav-Shah, Nirupama Masse, Stephanie L. Sherman

Genetic Networks of Liver Metabolism Revealed by Integration of Metabolic and Transcriptional Profiling

Christine T. Ferrara, Ping Wang, Elias Chaibub Neto, Robert D. Stevens, James R. Bain, Brett R. Wenner, Olga R. Ilkayeva, Mark P. Keller, Daniel A. Blasiole, Christina Kendziorski, Brian S. Yandell, Christopher B. Newgard, Alan D. Attie

Transcriptional Profiling Uncovers a Network of Cholesterol-Responsive Atherosclerosis Target Genes

Josefin Skogsberg, Jesper Lundström, Alexander Kovacs, Roland Nilsson, Peri Noori, Shohreh Maleki, Marina Köhler, Anders Hamsten, Jesper Tegnér, Johan Björkegren

ruvA Mutants That Resolve Holliday Junctions but Do Not Reverse Replication Forks

Zeynep Baharoglu, Alison Sylvia Bradley, Marie Le Masson, Irina Tsaneva, Bénédicte Michel

GADD45A Does Not Promote DNA Demethylation

Seung-Gi Jin, Cai Guo, Gerd P. Pfeifer

Transcription and Chromatin Organization of a Housekeeping Gene Cluster Containing an Integrated β-Globin Locus Control Region

Daan Noordermeer, Miguel R. Branco, Erik Splinter, Petra Klous, Wilfred van IJcken, Sigrid Swagemakers, Manousos Koutsourakis, Peter van der Spek, Ana Pombo, Wouter de Laat

Functional Characterization of Variations on Regulatory Motifs

Lapidot Michal, Orna Mizrahi-Man, Yitzhak Pilpel

Leukocyte Tyrosine Kinase Functions in Pigment Cell Development

Susana S. Lopes, Xueyan Yang, Jeanette Müller, Thomas J. Carney, Anthony R. McAdow, Gerd-Jörg Rauch, Arie S. Jacoby, Laurence D. Hurst, Mariana Delfino-Machín, Pascal Haffter, Robert Geisler, Stephen L. Johnson, Andrew Ward, Robert N. Kelsh