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Table of Contents: October 2010

COVER

Developing lung of a 12.5-day-old mouse embryo.

Image Credit: Ian Smyth
Issue Image

The lung and trachea originate in the ventral foregut, but their separation from the future oesophagus remains poorly understood. In this issue of PLoS Genetics, Jurado et al report that ASCIZ, a Zn2+-finger protein previously linked to the repair of methylating and oxidative DNA damage, also has an unexpected function during early lung development. Although embryos lacking Asciz are able to generate respiratory precursors, they never form lung buds, and separation of the trachea from the foregut stalls at an early stage. The authors propose that ASCIZ may function as a new transcriptional regulator of foregut separation.

Perspective

Research Articles

Altering a Histone H3K4 Methylation Pathway in Glomerular Podocytes Promotes a Chronic Disease Phenotype

Gaelle M. Lefevre, Sanjeevkumar R. Patel, Doyeob Kim, Lino Tessarollo, Gregory R. Dressler

Conserved Genes Act as Modifiers of Invertebrate SMN Loss of Function Defects

Maria Dimitriadi, James N. Sleigh, Amy Walker, Howard C. Chang, Anindya Sen, Geetika Kalloo, Jevede Harris, Tom Barsby, Melissa B. Walsh, John S. Satterlee, Chris Li, David Van Vactor, Spyros Artavanis-Tsakonas, Anne C. Hart

DSIF and RNA Polymerase II CTD Phosphorylation Coordinate the Recruitment of Rpd3S to Actively Transcribed Genes

Simon Drouin, Louise Laramée, Pierre-Étienne Jacques, Audrey Forest, Maxime Bergeron, François Robert

Stress-Induced Activation of Heterochromatic Transcription

Mireille Tittel-Elmer, Etienne Bucher, Larissa Broger, Olivier Mathieu, Jerzy Paszkowski, Isabelle Vaillant

Actin Depolymerizing Factors Cofilin1 and Destrin Are Required for Ureteric Bud Branching Morphogenesis

Satu Kuure, Cristina Cebrian, Quentin Machingo, Benson C. Lu, Xuan Chi, Deborah Hyink, Vivette D'Agati, Christine Gurniak, Walter Witke, Frank Costantini

Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension

Sandosh Padmanabhan, Olle Melander, Toby Johnson, Anna Maria Di Blasio, Wai K. Lee, Davide Gentilini, Claire E. Hastie, Cristina Menni, Maria Cristina Monti, Christian Delles, Stewart Laing, Barbara Corso, Gerjan Navis, Arjan J. Kwakernaak, Pim van der Harst, Murielle Bochud, Marc Maillard, Michel Burnier, Thomas Hedner, Sverre Kjeldsen, Björn Wahlstrand, Marketa Sjögren, Cristiano Fava, Martina Montagnana, Elisa Danese, Ole Torffvit, Bo Hedblad, Harold Snieder, John M. C. Connell, Morris Brown, Nilesh J. Samani, Martin Farrall, Giancarlo Cesana, Giuseppe Mancia, Stefano Signorini, Guido Grassi, Susana Eyheramendy, H. Erich Wichmann, Maris Laan, David P. Strachan, Peter Sever, Denis Colm Shields, Alice Stanton, Peter Vollenweider, Alexander Teumer, Henry Völzke, Rainer Rettig, Christopher Newton-Cheh, Pankaj Arora, Feng Zhang, Nicole Soranzo, Timothy D. Spector, Gavin Lucas, Sekar Kathiresan, David S. Siscovick, Jian'an Luan, Ruth J. F. Loos, Nicholas J. Wareham, Brenda W. Penninx, Ilja M. Nolte, Martin McBride, William H. Miller, Stuart A. Nicklin, Andrew H. Baker, Delyth Graham, Robert A. McDonald, Jill P. Pell, Naveed Sattar, Paul Welsh, Patricia Munroe, Mark J. Caulfield, Alberto Zanchetti, Anna F. Dominiczak , Global BPgen Consortium

Allele-Specific Down-Regulation of RPTOR Expression Induced by Retinoids Contributes to Climate Adaptations

Chang Sun, Catherine Southard, David B. Witonsky, Ralf Kittler, Anna Di Rienzo

The Meiotic Recombination Checkpoint Suppresses NHK-1 Kinase to Prevent Reorganisation of the Oocyte Nucleus in Drosophila

Oscar M. Lancaster, Manuel Breuer, C. Fiona Cullen, Takashi Ito, Hiroyuki Ohkura

Facioscapulohumeral Dystrophy: Incomplete Suppression of a Retrotransposed Gene

Lauren Snider, Linda N. Geng, Richard J. L. F. Lemmers, Michael Kyba, Carol B. Ware, Angelique M. Nelson, Rabi Tawil, Galina N. Filippova, Silvère M. van der Maarel, Stephen J. Tapscott, Daniel G. Miller

The De Novo Cytosine Methyltransferase DRM2 Requires Intact UBA Domains and a Catalytically Mutated Paralog DRM3 during RNA–Directed DNA Methylation in Arabidopsis thaliana

Ian R. Henderson, Angelique Deleris, William Wong, Xuehua Zhong, Hang Gyeong Chin, Gregory A. Horwitz, Krystyna A. Kelly, Sriharsa Pradhan, Steven E. Jacobsen

Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer

Mia M. Gaudet, Tomas Kirchhoff, Todd Green, Joseph Vijai, Joshua M. Korn, Candace Guiducci, Ayellet V. Segrè, Kate McGee, Lesley McGuffog, Christiana Kartsonaki, Jonathan Morrison, Sue Healey, Olga M. Sinilnikova, Dominique Stoppa-Lyonnet, Sylvie Mazoyer, Marion Gauthier-Villars, Hagay Sobol, Michel Longy, Marc Frenay, GEMO Study Collaborators, Frans B. L. Hogervorst, Matti A. Rookus, J. Margriet Collée, Nicoline Hoogerbrugge, Kees E. P. van Roozendaal, Marion Piedmonte, Wendy Rubinstein, Stacy Nerenstone, Linda Van Le, Stephanie V. Blank, Trinidad Caldés, Miguel de la Hoya, Heli Nevanlinna, Kristiina Aittomäki, Conxi Lazaro, Ignacio Blanco, Adalgeir Arason, Oskar T. Johannsson, Rosa B. Barkardottir, Peter Devilee, Olofunmilayo I. Olopade, Susan L. Neuhausen, Xianshu Wang, Zachary S. Fredericksen, Paolo Peterlongo, Siranoush Manoukian, Monica Barile, Alessandra Viel, Paolo Radice, Catherine M. Phelan, Steven Narod, Gad Rennert, Flavio Lejbkowicz, Anath Flugelman, Irene L. Andrulis, Gord Glendon, Hilmi Ozcelik, Amanda E. Toland, Marco Montagna, Emma D'Andrea, Eitan Friedman, Yael Laitman, Ake Borg, Mary Beattie, Susan J. Ramus, Susan M. Domchek, Katherine L. Nathanson, Tim Rebbeck, Amanda B. Spurdle, Xiaoqing Chen, Helene Holland, Esther M. John, John L. Hopper, Saundra S. Buys, Mary B. Daly, Melissa C. Southey, Mary Beth Terry, Nadine Tung, Thomas V. Overeem Hansen, Finn C. Nielsen, Mark I. Greene, Phuong L. Mai, Ana Osorio, Mercedes Durán, Raquel Andres, Javier Benítez, Jeffrey N. Weitzel, Judy Garber, Ute Hamann, Susan Peock, Margaret Cook, Clare Oliver, Debra Frost, Radka Platte, D. Gareth Evans, Fiona Lalloo, Ros Eeles, Louise Izatt, Lisa Walker, Jacqueline Eason, Julian Barwell, Andrew K. Godwin, Rita K. Schmutzler, Barbara Wappenschmidt, Stefanie Engert, Norbert Arnold, Dorothea Gadzicki, Michael Dean, Bert Gold, Robert J. Klein, Fergus J. Couch, Georgia Chenevix-Trench, Douglas F. Easton, Mark J. Daly, Antonis C. Antoniou, David M. Altshuler, Kenneth Offit , HEBON Study Collaborators, OCGN, kConFab

Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo

M. Kamran Ikram, Sim Xueling, Richard A. Jensen, Mary Frances Cotch, Alex W. Hewitt, M. Arfan Ikram, Jie Jin Wang, Ronald Klein, Barbara E. K. Klein, Monique M. B. Breteler, Ning Cheung, Gerald Liew, Paul Mitchell, Andre G. Uitterlinden, Fernando Rivadeneira, Albert Hofman, Paulus T. V. M. de Jong, Cornelia M. van Duijn, Linda Kao, Ching-Yu Cheng, Albert Vernon Smith, Nicole L. Glazer, Thomas Lumley, Barbara McKnight, Bruce M. Psaty, Fridbert Jonasson, Gudny Eiriksdottir, Thor Aspelund, Tamara B. Harris, Lenore J. Launer, Kent D. Taylor, Xiaohui Li, Sudha K. Iyengar, Quansheng Xi, Theru A. Sivakumaran, David A. Mackey, Stuart MacGregor, Nicholas G. Martin, Terri L. Young, Josh C. Bis, Kerri L. Wiggins, Susan R. Heckbert, Christopher J. Hammond, Toby Andrew, Samantha Fahy, John Attia, Elizabeth G. Holliday, Rodney J. Scott, F. M. Amirul Islam, Jerome I. Rotter, Annie K. McAuley, Eric Boerwinkle, E. Shyong Tai, Vilmundur Gudnason, David S. Siscovick, Johannes R. Vingerling, Tien Y. Wong , Global BPgen Consortium

Pervasive Cryptic Epistasis in Molecular Evolution

Mark Lunzer, G. Brian Golding, Antony M. Dean

Genome-Wide Identification of Targets and Function of Individual MicroRNAs in Mouse Embryonic Stem Cells

Sophie A. Hanina, William Mifsud, Thomas A. Down, Katsuhiko Hayashi, Dónal O'Carroll, Kaiqin Lao, Eric A. Miska, M. Azim Surani

Transition from Positive to Neutral in Mutation Fixation along with Continuing Rising Fitness in Thermal Adaptive Evolution

Toshihiko Kishimoto, Leo Iijima, Makoto Tatsumi, Naoaki Ono, Ayana Oyake, Tomomi Hashimoto, Moe Matsuo, Masato Okubo, Shingo Suzuki, Kotaro Mori, Akiko Kashiwagi, Chikara Furusawa, Bei-Wen Ying, Tetsuya Yomo

Evidence for a Xer/dif System for Chromosome Resolution in Archaea

Diego Cortez, Sophie Quevillon-Cheruel, Simonetta Gribaldo, Nicole Desnoues, Guennadi Sezonov, Patrick Forterre, Marie-Claude Serre

Genetic Association Study Identifies HSPB7 as a Risk Gene for Idiopathic Dilated Cardiomyopathy

Klaus Stark, Ulrike B. Esslinger, Wibke Reinhard, George Petrov, Thomas Winkler, Michel Komajda, Richard Isnard, Philippe Charron, Eric Villard, François Cambien, Laurence Tiret, Marie-Claude Aumont, Olivier Dubourg, Jean-Noël Trochu, Laurent Fauchier, Pascal DeGroote, Anette Richter, Bernhard Maisch, Thomas Wichter, Christa Zollbrecht, Martina Grassl, Heribert Schunkert, Patrick Linsel-Nitschke, Jeanette Erdmann, Jens Baumert, Thomas Illig, Norman Klopp, H.-Erich Wichmann, Christa Meisinger, Wolfgang Koenig, Peter Lichtner, Thomas Meitinger, Arne Schillert, Inke R. König, Roland Hetzer, Iris M. Heid, Vera Regitz-Zagrosek, Christian Hengstenberg

Loss of the p53/p63 Regulated Desmosomal Protein Perp Promotes Tumorigenesis

Veronica G. Beaudry, Dadi Jiang, Rachel L. Dusek, Eunice J. Park, Stevan Knezevich, Katie Ridd, Hannes Vogel, Boris C. Bastian, Laura D. Attardi

Ancient and Recent Adaptive Evolution of Primate Non-Homologous End Joining Genes

Ann Demogines, Alysia M. East, Ji-Hoon Lee, Sharon R. Grossman, Pardis C. Sabeti, Tanya T. Paull, Sara L. Sawyer

Dual Functions of ASCIZ in the DNA Base Damage Response and Pulmonary Organogenesis

Sabine Jurado, Ian Smyth, Bryce van Denderen, Nora Tenis, Andrew Hammet, Kimberly Hewitt, Jane-Lee Ng, Carolyn J. McNees, Sergei V. Kozlov, Hayato Oka, Masahiko Kobayashi, Lindus A. Conlan, Timothy J. Cole, Ken-ichi Yamamoto, Yoshihito Taniguchi, Shunichi Takeda, Martin F. Lavin, Jörg Heierhorst

Characterising and Predicting Haploinsufficiency in the Human Genome

Ni Huang, Insuk Lee, Edward M. Marcotte, Matthew E. Hurles

Comprehensive Analysis Reveals Dynamic and Evolutionary Plasticity of Rab GTPases and Membrane Traffic in Tetrahymena thermophila

Lydia J. Bright, Nichole Kambesis, Scott Brent Nelson, Byeongmoon Jeong, Aaron P. Turkewitz

Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation

Aida M. Andrés, Megan Y. Dennis, Warren W. Kretzschmar, Jennifer L. Cannons, Shih-Queen Lee-Lin, Belen Hurle, Pamela L. Schwartzberg, Scott H. Williamson, Carlos D. Bustamante, Rasmus Nielsen, Andrew G. Clark, Eric D. Green , NISC Comparative Sequencing Program

Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila

Benoît Biteau, Jason Karpac, Stephen Supoyo, Matthew DeGennaro, Ruth Lehmann, Heinrich Jasper

Gimap3 Regulates Tissue-Specific Mitochondrial DNA Segregation

Riikka Jokinen, Paula Marttinen, Helen Katarin Sandell, Tuula Manninen, Heli Teerenhovi, Timothy Wai, Daniella Teoli, J. C. Loredo-Osti, Eric A. Shoubridge, Brendan J. Battersby

Tight Regulation of the intS Gene of the KplE1 Prophage: A New Paradigm for Integrase Gene Regulation

Gaël Panis, Yohann Duverger, Elise Courvoisier-Dezord, Stéphanie Champ, Emmanuel Talla, Mireille Ansaldi

Characterization of LINE-1 Ribonucleoprotein Particles

Aurélien J. Doucet, Amy E. Hulme, Elodie Sahinovic, Deanna A. Kulpa, John B. Moldovan, Huira C. Kopera, Jyoti N. Athanikar, Manel Hasnaoui, Alain Bucheton, John V. Moran, Nicolas Gilbert

Simultaneous Disruption of Two DNA Polymerases, Polη and Polζ, in Avian DT40 Cells Unmasks the Role of Polη in Cellular Response to Various DNA Lesions

Kouji Hirota, Eiichiro Sonoda, Takuo Kawamoto, Akira Motegi, Chikahide Masutani, Fumio Hanaoka, Dávid Szüts, Shigenori Iwai, Julian E. Sale, Alan Lehmann, Shunichi Takeda

H3K27me3 Profiling of the Endosperm Implies Exclusion of Polycomb Group Protein Targeting by DNA Methylation

Isabelle Weinhofer, Elisabeth Hehenberger, Pawel Roszak, Lars Hennig, Claudia Köhler

Alternative Splicing at a NAGNAG Acceptor Site as a Novel Phenotype Modifier

Alexandre Hinzpeter, Abdel Aissat, Elvira Sondo, Catherine Costa, Nicole Arous, Christine Gameiro, Natacha Martin, Agathe Tarze, Laurence Weiss, Alix de Becdelièvre, Bruno Costes, Michel Goossens, Luis J. Galietta, Emmanuelle Girodon, Pascale Fanen